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Oxidants, oxidative stress and the biology of ageing

Author

Listed:
  • Toren Finkel

    (Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute/National Institutes of Health, Building 10/6N-240)

  • Nikki J. Holbrook

    (Laboratory of Biological Chemistry, National Institute on Aging/National Institutes of Health)

Abstract

Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.

Suggested Citation

  • Toren Finkel & Nikki J. Holbrook, 2000. "Oxidants, oxidative stress and the biology of ageing," Nature, Nature, vol. 408(6809), pages 239-247, November.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6809:d:10.1038_35041687
    DOI: 10.1038/35041687
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    9. K. A. Gajewska & H. Lescesen & M. Ramialison & K. M. Wagstaff & D. A. Jans, 2021. "Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    10. Victória Assis & Ivo Vieira de Sousa Neto & Filipe M. Ribeiro & Rita de Cassia Marqueti & Octávio Luiz Franco & Samuel da Silva Aguiar & Bernardo Petriz, 2022. "The Emerging Role of the Aging Process and Exercise Training on the Crosstalk between Gut Microbiota and Telomere Length," IJERPH, MDPI, vol. 19(13), pages 1-11, June.
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    12. Marc Thilo Figge & Andreas S Reichert & Michael Meyer-Hermann & Heinz D Osiewacz, 2012. "Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging," PLOS Computational Biology, Public Library of Science, vol. 8(6), pages 1-18, June.
    13. Xinyue Zhang & Xiaolu Gao & Danxian Wu & Zening Xu & Hongjie Wang, 2021. "The Role of Big Data in Aging and Older People’s Health Research: A Systematic Review and Ecological Framework," Sustainability, MDPI, vol. 13(21), pages 1-19, October.
    14. Mustafa Mortas, 2023. "Characterization of a New Powdered, Milk-Based Medicinal Plant ( Alcea rosea ) Drink Product," Sustainability, MDPI, vol. 15(12), pages 1-14, June.
    15. Mohamed Saber Numan & Jacques P. Brown & Laëtitia Michou, 2015. "Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases," IJERPH, MDPI, vol. 12(2), pages 1-17, February.
    16. Onni Niemelä, 2016. "Biomarker-Based Approaches for Assessing Alcohol Use Disorders," IJERPH, MDPI, vol. 13(2), pages 1-19, January.
    17. Panduranga Murthy G & Leelaja BC & Ravishankar HG & Dharshan Raj CG & Rajesh Kumar, 2018. "Evaluation of Neuroprotection and Antioxidant Activities via Drosophila Model System in the Active Principle Derived from Sida Glutinosa Comm. Ex Cav. - An Aboriginal Ethno-Medicinal Plant Drug Practi," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 11(5), pages 8855-8862, December.
    18. Mirre J P Simons & Alan A Cohen & Simon Verhulst, 2012. "What Does Carotenoid-Dependent Coloration Tell? Plasma Carotenoid Level Signals Immunocompetence and Oxidative Stress State in Birds–A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-1, August.
    19. Akiko Koto & Makoto Tamura & Pui Shan Wong & Sachiyo Aburatani & Eyal Privman & Céline Stoffel & Alessandro Crespi & Sean Keane McKenzie & Christine Mendola & Tomas Kay & Laurent Keller, 2023. "Social isolation shortens lifespan through oxidative stress in ants," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    20. Daniel L Belavý & Ulf Gast & Martin Daumer & Elena Fomina & Rainer Rawer & Hans Schießl & Stefan Schneider & Harald Schubert & Cristina Soaz & Dieter Felsenberg, 2013. "Progressive Adaptation in Physical Activity and Neuromuscular Performance during 520d Confinement," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-7, March.
    21. Natasha B. Scott & Nicola S. Pocock, 2021. "The Health Impacts of Hazardous Chemical Exposures among Child Labourers in Low- and Middle-Income Countries," IJERPH, MDPI, vol. 18(10), pages 1-34, May.

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