IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v4y2013i1d10.1038_ncomms2376.html
   My bibliography  Save this article

On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

Author

Listed:
  • Esther Krook-Magnuson

    (University of California)

  • Caren Armstrong

    (University of California)

  • Mikko Oijala

    (University of California)

  • Ivan Soltesz

    (University of California)

Abstract

Temporal lobe epilepsy is the most common type of epilepsy in adults, is often medically refractory, and due to broad actions and long-time scales, current systemic treatments have major negative side-effects. However, temporal lobe seizures tend to arise from discrete regions before overt clinical behaviour, making temporally and spatially specific treatment theoretically possible. Here we report the arrest of spontaneous seizures using a real-time, closed-loop, response system and in vivo optogenetics in a mouse model of temporal lobe epilepsy. Either optogenetic inhibition of excitatory principal cells, or activation of a subpopulation of GABAergic cells representing

Suggested Citation

  • Esther Krook-Magnuson & Caren Armstrong & Mikko Oijala & Ivan Soltesz, 2013. "On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy," Nature Communications, Nature, vol. 4(1), pages 1-8, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2376
    DOI: 10.1038/ncomms2376
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms2376
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms2376?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wonok Kang & Chanyang Ju & Jaesoon Joo & Jiho Lee & Young-Min Shon & Sung-Min Park, 2022. "Closed-loop direct control of seizure focus in a rodent model of temporal lobe epilepsy via localized electric fields applied sequentially," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. John-Sebastian Mueller & Fabio C. Tescarollo & Trong Huynh & Daniel A. Brenner & Daniel J. Valdivia & Kanyin Olagbegi & Sahana Sangappa & Spencer C. Chen & Hai Sun, 2023. "Ictogenesis proceeds through discrete phases in hippocampal CA1 seizures in mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. James Okoh & Jacqunae Mays & Alexandre Bacq & Juan A. Oses-Prieto & Stefka Tyanova & Chien-Ju Chen & Khalel Imanbeyev & Marion Doladilhe & Hongyi Zhou & Paymaan Jafar-Nejad & Alma Burlingame & Jeffrey, 2023. "Targeted suppression of mTORC2 reduces seizures across models of epilepsy," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Quynh-Anh Nguyen & Peter M. Klein & Cheng Xie & Katelyn N. Benthall & Jillian Iafrati & Jesslyn Homidan & Jacob T. Bendor & Barna Dudok & Jordan S. Farrell & Tilo Gschwind & Charlotte L. Porter & Anna, 2024. "Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Zhao, Jinyi & Yu, Ying & Wang, Qingyun, 2022. "Dynamical regulation of epileptiform discharges caused by abnormal astrocyte function with optogenetic stimulation," Chaos, Solitons & Fractals, Elsevier, vol. 164(C).
    6. Jung Ho Hyun & Kenichiro Nagahama & Ho Namkung & Neymi Mignocchi & Seung-Eon Roh & Patrick Hannan & Sarah Krüssel & Chuljung Kwak & Abigail McElroy & Bian Liu & Mingguang Cui & Seunghwan Lee & Dongmin, 2022. "Tagging active neurons by soma-targeted Cal-Light," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2376. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.