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Closed-loop direct control of seizure focus in a rodent model of temporal lobe epilepsy via localized electric fields applied sequentially

Author

Listed:
  • Wonok Kang

    (Pohang University of Science and Technology
    Pohang University of Science and Technology)

  • Chanyang Ju

    (Pohang University of Science and Technology
    Pohang University of Science and Technology)

  • Jaesoon Joo

    (Sungkyunkwan University)

  • Jiho Lee

    (Pohang University of Science and Technology
    Pohang University of Science and Technology)

  • Young-Min Shon

    (Sungkyunkwan University
    Sungkyunkwan University)

  • Sung-Min Park

    (Pohang University of Science and Technology
    Pohang University of Science and Technology
    Pohang University of Science and Technology
    Pohang University of Science and Technology)

Abstract

Direct electrical stimulation of the seizure focus can achieve the early termination of epileptic oscillations. However, direct intervention of the hippocampus, the most prevalent seizure focus in temporal lobe epilepsy is thought to be not practicable due to its large size and elongated shape. Here, in a rat model, we report a sequential narrow-field stimulation method for terminating seizures, while focusing stimulus energy at the spatially extensive hippocampal structure. The effects and regional specificity of this method were demonstrated via electrophysiological and biological responses. Our proposed modality demonstrates spatiotemporal preciseness and selectiveness for modulating the pathological target region which may have potential for further investigation as a therapeutic approach.

Suggested Citation

  • Wonok Kang & Chanyang Ju & Jaesoon Joo & Jiho Lee & Young-Min Shon & Sung-Min Park, 2022. "Closed-loop direct control of seizure focus in a rodent model of temporal lobe epilepsy via localized electric fields applied sequentially," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35540-7
    DOI: 10.1038/s41467-022-35540-7
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    References listed on IDEAS

    as
    1. Yi Lu & Cheng Zhong & Lulu Wang & Pengfei Wei & Wei He & Kang Huang & Yi Zhang & Yang Zhan & Guoping Feng & Liping Wang, 2016. "Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures," Nature Communications, Nature, vol. 7(1), pages 1-12, April.
    2. Esther Krook-Magnuson & Caren Armstrong & Mikko Oijala & Ivan Soltesz, 2013. "On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy," Nature Communications, Nature, vol. 4(1), pages 1-8, June.
    3. Yi Lu & Cheng Zhong & Lulu Wang & Pengfei Wei & Wei He & Kang Huang & Yi Zhang & Yang Zhan & Guoping Feng & Liping Wang, 2016. "Correction: Corrigendum: Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures," Nature Communications, Nature, vol. 7(1), pages 1-1, November.
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