IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-64416-9.html
   My bibliography  Save this article

Status dystonicus is a distinct state characterized by pallidal beta-band activity

Author

Listed:
  • Arjun Balachandar

    (University of Toronto
    University of Toronto
    University of Toronto
    Krembil Research Institute)

  • Lindsey M. Vogt

    (University of Toronto)

  • Karim Mithani

    (University of Toronto)

  • Sebastian C. Coleman

    (University of Toronto)

  • Mark Ebden

    (University of Toronto)

  • Andrea Leblanc-Miller

    (University of Toronto)

  • Sara Breitbart

    (University of Toronto)

  • Alfonso Fasano

    (University of Toronto
    University of Toronto
    Krembil Research Institute
    20090 Pieve Emanuele)

  • Carolina Gorodetsky

    (University of Toronto)

  • George M. Ibrahim

    (University of Toronto)

Abstract

Status dystonicus (SD) is a poorly known neurological emergency requiring urgent interventions, including deep brain stimulation (DBS) targeting the globus pallidus interna (GPi). The sensing capabilities of DBS electrodes provide an opportunity to study the pathophysiology of SD. Here, we study local field potentials (LFPs) from GPi-DBS electrodes implanted in a cohort of 10 children longitudinally during SD, recovery and relapse (recording range 11-1155 days). During SD, we report an increase in the periodic component of the power spectrum within the beta-band along with increases in burst amplitude compared to recordings in non-SD states. Furthermore, relapsed SD is characterized by a return of excessive beta signatures. Beta-specific LFP power is also significantly associated with worse quality-of-life scores (PedsQL, R2 = 0.695). We identify circadian pallidal beta-band periodicity in one participant with chronic narrowband beta-power recordings over months, with significant increase in power during SD. These rare recordings in children with SD point to excessive pallidal beta-band activity as a biomarker of SD. Our findings further suggest that SD is a distinct state with important implications for understanding dystonia pathophysiology, tracking dystonia states from intracranial activity and potential adaptive DBS treatments.

Suggested Citation

  • Arjun Balachandar & Lindsey M. Vogt & Karim Mithani & Sebastian C. Coleman & Mark Ebden & Andrea Leblanc-Miller & Sara Breitbart & Alfonso Fasano & Carolina Gorodetsky & George M. Ibrahim, 2025. "Status dystonicus is a distinct state characterized by pallidal beta-band activity," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64416-9
    DOI: 10.1038/s41467-025-64416-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-64416-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-64416-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jackson N. Cagle & Tiberio de Araujo & Kara A. Johnson & John Yu & Lauren Fanty & Filipe P. Sarmento & Simon Little & Michael S. Okun & Joshua K. Wong & Coralie de Hemptinne, 2024. "Chronic intracranial recordings in the globus pallidus reveal circadian rhythms in Parkinson’s disease," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    2. Md Fahim Anjum & Clay Smyth & Rafael Zuzuárregui & Derk Jan Dijk & Philip A. Starr & Timothy Denison & Simon Little, 2024. "Multi-night cortico-basal recordings reveal mechanisms of NREM slow-wave suppression and spontaneous awakenings in Parkinson’s disease," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Roxanne Lofredi & Lucia K. Feldmann & Patricia Krause & Ute Scheller & Wolf-Julian Neumann & Joachim K. Krauss & Assel Saryyeva & Gerd-Helge Schneider & Katharina Faust & Tilmann Sander & Andrea A. Kü, 2024. "Striato-pallidal oscillatory connectivity correlates with symptom severity in dystonia patients," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    4. Maxime O. Baud & Jonathan K. Kleen & Emily A. Mirro & Jason C. Andrechak & David King-Stephens & Edward F. Chang & Vikram R. Rao, 2018. "Multi-day rhythms modulate seizure risk in epilepsy," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Isabella Marinelli & Jamie J Walker & Udaya Seneviratne & Wendyl D’Souza & Mark J Cook & Clare Anderson & Andrew P Bagshaw & Stafford L Lightman & Wessel Woldman & John R Terry, 2023. "Circadian distribution of epileptiform discharges in epilepsy: Candidate mechanisms of variability," PLOS Computational Biology, Public Library of Science, vol. 19(10), pages 1-19, October.
    2. Annika Hagemann & Jens Wilting & Bita Samimizad & Florian Mormann & Viola Priesemann, 2021. "Assessing criticality in pre-seizure single-neuron activity of human epileptic cortex," PLOS Computational Biology, Public Library of Science, vol. 17(3), pages 1-18, March.
    3. Yuhao Huang & Jeffrey B. Wang & Jonathon J. Parker & Rajat Shivacharan & Rayhan A. Lal & Casey H. Halpern, 2023. "Spectro-spatial features in distributed human intracranial activity proactively encode peripheral metabolic activity," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    4. Tao Zhang & Haoyuan Hu & Hong Jiang & Zhen Wang & Jinfeng Lin & Ye Cheng & Wei Guo & Di Ke & Hai Hang & Mengshu Ta & Jun Ou-Yang & Jiwei Zhai & Xiaofei Yang & Songyun Wang & Benpeng Zhu, 2025. "KNN-based frequency-adjustable ferroelectric heterojunction and biomedical applications," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    5. Enrico Pracucci & Robert T. Graham & Laura Alberio & Gabriele Nardi & Olga Cozzolino & Vinoshene Pillai & Giacomo Pasquini & Luciano Saieva & Darren Walsh & Silvia Landi & Jinwei Zhang & Andrew J. Tre, 2023. "Daily rhythm in cortical chloride homeostasis underpins functional changes in visual cortex excitability," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64416-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.