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Chronic intracranial recordings in the globus pallidus reveal circadian rhythms in Parkinson’s disease

Author

Listed:
  • Jackson N. Cagle

    (University of Florida
    University of Florida)

  • Tiberio de Araujo

    (University of Florida)

  • Kara A. Johnson

    (University of Florida
    University of Florida)

  • John Yu

    (University of Florida
    University of Florida)

  • Lauren Fanty

    (University of Florida
    University of Florida)

  • Filipe P. Sarmento

    (University of Florida)

  • Simon Little

    (University of California San Francisco)

  • Michael S. Okun

    (University of Florida
    University of Florida)

  • Joshua K. Wong

    (University of Florida
    University of Florida)

  • Coralie de Hemptinne

    (University of Florida
    University of Florida)

Abstract

Circadian rhythms have been shown in the subthalamic nucleus (STN) in Parkinson’s disease (PD), but only a few studies have focused on the globus pallidus internus (GPi). This retrospective study investigates GPi circadian rhythms in a large cohort of subjects with PD (130 recordings from 93 subjects) with GPi activity chronically recorded in their home environment. We found a significant change in GPi activity between daytime and nighttime in most subjects (82.4%), with a reduction in GPi activity at nighttime in 56.2% of recordings and an increase in activity in 26.2%. GPi activity in higher frequency bands ( > 20 Hz) was more likely to decrease at night and in patients taking extended-release levodopa medication. Our results suggest that circadian fluctuations in the GPi vary across individuals and that increased power at night might be due to the reemergence of pathological neural activity. These findings should be considered to ensure successful implementation of adaptive neurostimulation paradigms in the real-world.

Suggested Citation

  • Jackson N. Cagle & Tiberio de Araujo & Kara A. Johnson & John Yu & Lauren Fanty & Filipe P. Sarmento & Simon Little & Michael S. Okun & Joshua K. Wong & Coralie de Hemptinne, 2024. "Chronic intracranial recordings in the globus pallidus reveal circadian rhythms in Parkinson’s disease," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48732-0
    DOI: 10.1038/s41467-024-48732-0
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    References listed on IDEAS

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    1. Zixiao Yin & Ruoyu Ma & Qi An & Yichen Xu & Yifei Gan & Guanyu Zhu & Yin Jiang & Ning Zhang & Anchao Yang & Fangang Meng & Andrea A. Kühn & Hagai Bergman & Wolf-Julian Neumann & Jianguo Zhang, 2023. "Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Marianne L. Seney & Kelly Cahill & John F. Enwright & Ryan W. Logan & Zhiguang Huo & Wei Zong & George Tseng & Colleen A. McClung, 2019. "Diurnal rhythms in gene expression in the prefrontal cortex in schizophrenia," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
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    Cited by:

    1. Arjun Balachandar & Lindsey M. Vogt & Karim Mithani & Sebastian C. Coleman & Mark Ebden & Andrea Leblanc-Miller & Sara Breitbart & Alfonso Fasano & Carolina Gorodetsky & George M. Ibrahim, 2025. "Status dystonicus is a distinct state characterized by pallidal beta-band activity," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    2. Tao Zhang & Haoyuan Hu & Hong Jiang & Zhen Wang & Jinfeng Lin & Ye Cheng & Wei Guo & Di Ke & Hai Hang & Mengshu Ta & Jun Ou-Yang & Jiwei Zhai & Xiaofei Yang & Songyun Wang & Benpeng Zhu, 2025. "KNN-based frequency-adjustable ferroelectric heterojunction and biomedical applications," Nature Communications, Nature, vol. 16(1), pages 1-11, December.

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