IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-017-02577-y.html
   My bibliography  Save this article

Multi-day rhythms modulate seizure risk in epilepsy

Author

Listed:
  • Maxime O. Baud

    (University of California
    University Hospital Geneva
    Wyss Center for Bio and Neuroengineering
    University of Bern)

  • Jonathan K. Kleen

    (University of California)

  • Emily A. Mirro

    (NeuroPace, Inc.)

  • Jason C. Andrechak

    (University of Delaware)

  • David King-Stephens

    (California Pacific Medical Center)

  • Edward F. Chang

    (University of California)

  • Vikram R. Rao

    (University of California)

Abstract

Epilepsy is defined by the seemingly random occurrence of spontaneous seizures. The ability to anticipate seizures would enable preventative treatment strategies. A central but unresolved question concerns the relationship of seizure timing to fluctuating rates of interictal epileptiform discharges (here termed interictal epileptiform activity, IEA), a marker of brain irritability observed between seizures by electroencephalography (EEG). Here, in 37 subjects with an implanted brain stimulation device that detects IEA and seizures over years, we find that IEA oscillates with circadian and subject-specific multidien (multi-day) periods. Multidien periodicities, most commonly 20–30 days in duration, are robust and relatively stable for up to 10 years in men and women. We show that seizures occur preferentially during the rising phase of multidien IEA rhythms. Combining phase information from circadian and multidien IEA rhythms provides a novel biomarker for determining relative seizure risk with a large effect size in most subjects.

Suggested Citation

  • Maxime O. Baud & Jonathan K. Kleen & Emily A. Mirro & Jason C. Andrechak & David King-Stephens & Edward F. Chang & Vikram R. Rao, 2018. "Multi-day rhythms modulate seizure risk in epilepsy," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02577-y
    DOI: 10.1038/s41467-017-02577-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-02577-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-02577-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Enrico Pracucci & Robert T. Graham & Laura Alberio & Gabriele Nardi & Olga Cozzolino & Vinoshene Pillai & Giacomo Pasquini & Luciano Saieva & Darren Walsh & Silvia Landi & Jinwei Zhang & Andrew J. Tre, 2023. "Daily rhythm in cortical chloride homeostasis underpins functional changes in visual cortex excitability," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Yuhao Huang & Jeffrey B. Wang & Jonathon J. Parker & Rajat Shivacharan & Rayhan A. Lal & Casey H. Halpern, 2023. "Spectro-spatial features in distributed human intracranial activity proactively encode peripheral metabolic activity," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Annika Hagemann & Jens Wilting & Bita Samimizad & Florian Mormann & Viola Priesemann, 2021. "Assessing criticality in pre-seizure single-neuron activity of human epileptic cortex," PLOS Computational Biology, Public Library of Science, vol. 17(3), pages 1-18, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02577-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.