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Arabidopsis response to the apocarotenoid zaxinone involves interference with strigolactone signaling via binding to DWARF14

Author

Listed:
  • Juan C. Moreno

    (King Abdullah University of Science and Technology
    King Abdullah University of Science and Technology (KAUST))

  • Umar F. Shahul Hameed

    (King Abdullah University of Science and Technology (KAUST)
    King Abdullah University of Science and Technology)

  • Aparna Balakrishna

    (King Abdullah University of Science and Technology
    King Abdullah University of Science and Technology (KAUST))

  • Abdugaffor Ablazov

    (King Abdullah University of Science and Technology
    King Abdullah University of Science and Technology (KAUST))

  • Kit Xi Liew

    (King Abdullah University of Science and Technology
    King Abdullah University of Science and Technology (KAUST))

  • Muhammad Jamil

    (King Abdullah University of Science and Technology
    King Abdullah University of Science and Technology (KAUST))

  • Jianing Mi

    (King Abdullah University of Science and Technology
    King Abdullah University of Science and Technology (KAUST)
    Guangdong Provincial Academy of Chinese Medical Sciences)

  • Kawthar Alashoor

    (King Abdullah University of Science and Technology
    King Abdullah University of Science and Technology (KAUST))

  • Alexandre de Saint Germain

    (Institut Jean-Pierre Bourgin (IJPB))

  • Stefan T. Arold

    (King Abdullah University of Science and Technology (KAUST)
    King Abdullah University of Science and Technology)

  • Salim Al-Babili

    (King Abdullah University of Science and Technology
    King Abdullah University of Science and Technology (KAUST))

Abstract

The natural growth regulator zaxinone increases the levels of the phytohormones strigolactone (SL) and abscisic acid in Arabidopsis (Arabidopsis thaliana) via unknown mechanisms. Here we demonstrate that part of the effect of zaxinone in Arabidopsis depend on the SL receptor DWARF14 (AtD14) and the F-Box protein MORE AXILLARY BRANCHING2 (AtMAX2) that mediate the signaling of SLs and karrikins. Binding assays and co-crystallization reveal zaxinone as an additional ligand of AtD14 and an SL antagonist that interrupts the interaction of AtD14 with AtMAX2. Zaxinone also binds to the karrikin receptor KARRIKIN INSENSITIVE2 (AtKAI2). These findings unveil a perception mechanism for zaxinone in Arabidopsis and demonstrate the capability of AtD14 to bind signaling molecules, other than strigolactones and mediate their transduction.

Suggested Citation

  • Juan C. Moreno & Umar F. Shahul Hameed & Aparna Balakrishna & Abdugaffor Ablazov & Kit Xi Liew & Muhammad Jamil & Jianing Mi & Kawthar Alashoor & Alexandre de Saint Germain & Stefan T. Arold & Salim A, 2025. "Arabidopsis response to the apocarotenoid zaxinone involves interference with strigolactone signaling via binding to DWARF14," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-63845-w
    DOI: 10.1038/s41467-025-63845-w
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