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Regenerating aged bone marrow via a nitric oxide nanopump

Author

Listed:
  • Ke Li

    (Yangzhou University
    Affiliated Hospital of Yangzhou University
    The Key Laboratory of the Jiangsu Higher Education Institutions for Nucleic Acid & Cell Fate Regulation)

  • Sihan Hu

    (Yangzhou University
    The Key Laboratory of the Jiangsu Higher Education Institutions for Nucleic Acid & Cell Fate Regulation)

  • Hanwen Li

    (Affiliated Hospital of Yangzhou University
    The Key Laboratory of the Jiangsu Higher Education Institutions for Nucleic Acid & Cell Fate Regulation)

  • Wenzheng Lin

    (Yangzhou University
    Affiliated Hospital of Yangzhou University
    The Key Laboratory of the Jiangsu Higher Education Institutions for Nucleic Acid & Cell Fate Regulation)

  • Duoyi Zhao

    (Yangzhou University
    Affiliated Hospital of Yangzhou University
    The Key Laboratory of the Jiangsu Higher Education Institutions for Nucleic Acid & Cell Fate Regulation)

  • Zhuobin Xu

    (Yangzhou University
    The Key Laboratory of the Jiangsu Higher Education Institutions for Nucleic Acid & Cell Fate Regulation)

  • Chun Pan

    (Yangzhou University
    The Key Laboratory of the Jiangsu Higher Education Institutions for Nucleic Acid & Cell Fate Regulation)

  • Huihui Wang

    (Yangzhou University
    The Key Laboratory of the Jiangsu Higher Education Institutions for Nucleic Acid & Cell Fate Regulation)

  • Dandan Li

    (Yangzhou University
    The Key Laboratory of the Jiangsu Higher Education Institutions for Nucleic Acid & Cell Fate Regulation)

  • Jingjing Liu

    (Yangzhou University
    The Key Laboratory of the Jiangsu Higher Education Institutions for Nucleic Acid & Cell Fate Regulation)

  • Hao Chen

    (Yangzhou University
    Affiliated Hospital of Yangzhou University
    The Key Laboratory of the Jiangsu Higher Education Institutions for Nucleic Acid & Cell Fate Regulation)

Abstract

Resident leptin-receptor-expressing (LepR+) cells senescence in the aged bone marrow impairs the regenerative capacity of osteo- and other lineages of cells. In this study, a LepR+ cell-targeting nitric oxide (NO) nanopump with in vivo self-controlled turn-on ability was constructed to rejuvenate the LepR+ cells in the aged bone marrow. The nanopump co-entrapped hydrophobic chemiluminescence substrate and NO donor into the matrix of amphiphilic polymer through a nanoprecipitation process. The chemiluminescence substrate in the NO nanopump automatically reacts with the accumulated H2O2 in the aged bone marrow and then directly transfers the chemical energy to the NO donor to induce in situ NO release. The NO produced in situ within the aged bone marrow triggered the regeneration of the osteoblastic and the other niches in vivo through activating the glycolysis signaling in the senescent LepR+ cells. Conclusively, the constructed NO nanopump is a promising tool to counter aging-induced bone marrow disorders.

Suggested Citation

  • Ke Li & Sihan Hu & Hanwen Li & Wenzheng Lin & Duoyi Zhao & Zhuobin Xu & Chun Pan & Huihui Wang & Dandan Li & Jingjing Liu & Hao Chen, 2025. "Regenerating aged bone marrow via a nitric oxide nanopump," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61256-5
    DOI: 10.1038/s41467-025-61256-5
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