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Fumarylacetoacetate hydrolase targeted by a Fusarium graminearum effector positively regulates wheat FHB resistance

Author

Listed:
  • Shengping Shang

    (Chinese Academy of Agricultural Sciences
    Henan Agricultural University)

  • Yuhan He

    (Chinese Academy of Agricultural Sciences)

  • Ruihua Zhao

    (Chinese Academy of Agricultural Sciences
    Murdoch University)

  • Hanqi Li

    (Chinese Academy of Agricultural Sciences
    Shanxi Agricultural University)

  • Ying Fang

    (Chinese Academy of Agricultural Sciences
    Huazhong Agricultural University)

  • Qianyong Hu

    (Chinese Academy of Agricultural Sciences)

  • Yujin Fan

    (Chinese Academy of Agricultural Sciences)

  • Yiwei Wang

    (Chinese Academy of Agricultural Sciences
    Taiyuan University of Technology)

  • Xishi Zhou

    (Chinese Academy of Agricultural Sciences)

  • Penghao Wang

    (Murdoch University
    Murdoch University)

  • Xiaoping Xing

    (Henan Agricultural University)

  • Cui-Jun Zhang

    (Chinese Academy of Agricultural Sciences)

Abstract

Fusarium head blight (FHB), caused by Fusarium graminearum is a devastating disease that affects global wheat production. F. graminearum encodes many effector proteins; however, its virulence mechanisms are poorly understood. In this study, we identify a secretory effector candidate (FgEC10) that is essential for the virulence of F. graminearum. FgEC10 interacts strongly with wheat fumarylacetoacetate hydrolase (TaFAH) and accelerates its degradation via the 26S proteasome pathway. In addition, we show that TaFAH interacts with proteasome 26S subunit, non-ATPases 12 (TaPSMD12) and that FgEC10 enhances the interaction between TaFAH and TaPSMD12. RNA silencing or overexpression of TaFAH in wheat plants shows that TaFAH positively regulates wheat FHB resistance. Overexpression of TaFAH promotes the expression of genes associated with disease resistance and the heading period. Metabolomic analysis reveals that overexpression of TaFAH increases the levels of several amino acids in wheat, and exogenous application of some of these amino acids show an increase in F. graminearum resistance in the wheat spike and seedling. Collectively, our study reveals a pathogenic mechanism and provides a valuable gene resource for improving FHB resistance and promoting heading in wheat.

Suggested Citation

  • Shengping Shang & Yuhan He & Ruihua Zhao & Hanqi Li & Ying Fang & Qianyong Hu & Yujin Fan & Yiwei Wang & Xishi Zhou & Penghao Wang & Xiaoping Xing & Cui-Jun Zhang, 2025. "Fumarylacetoacetate hydrolase targeted by a Fusarium graminearum effector positively regulates wheat FHB resistance," Nature Communications, Nature, vol. 16(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60736-y
    DOI: 10.1038/s41467-025-60736-y
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