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A TaSnRK1α-TaCAT2 model mediates resistance to Fusarium crown rot by scavenging ROS in common wheat

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Listed:
  • Xia Yang

    (Henan Agricultural University)

  • Leilei Zhang

    (Henan Agricultural University)

  • Jiajie Wei

    (Henan Agricultural University)

  • Lexin Liu

    (Henan Agricultural University)

  • Di Liu

    (Henan Agricultural University)

  • Xiangning Yan

    (Henan Agricultural University)

  • Minjie Yuan

    (Henan Agricultural University)

  • Lingran Zhang

    (Henan Agricultural University)

  • Ning Zhang

    (Henan Agricultural University)

  • Yan Ren

    (Henan Agricultural University)

  • Feng Chen

    (Henan Agricultural University)

Abstract

Fusarium crown rot (FCR) is a serious underlying disease to threaten wheat yield and quality recently. Here, we identify a catalase antioxidant enzyme (TaCAT2) through genome wide association study (GWAS) and whole-exome sequencing (WES) in two nested bi-parental populations. We verify the function of TaCAT2 regulating wheat FCR resistance by genetic transformation. Moreover, we screen a sucrose non-fermenting-1-related protein kinase alpha subunit (TaSnRK1α) interacting with TaCAT2, and subsequently find that TaSnRK1α phosphorylates TaCAT2. We next identify an FCR-resistance haplotype TaCAT2Ser214, and confirm that Ser214 of TaCAT2 is a key phosphorylation site for TaSnRK1α. We also find that TaSnRK1α results in higher protein accumulation in TaCAT2Ser214 than in TaCAT2Thr214, which possibly contribute to scavenging ROS (reactive oxygen species) in TaCAT2Ser214 wheat plants. Furthermore, the function of TaSnRK1α regulating FCR resistance is verified by genetic transformation. Taken together, we propose a TaSnRK1α-TaCAT2 model to mediate FCR resistance by scavenging the ROS in wheat plants.

Suggested Citation

  • Xia Yang & Leilei Zhang & Jiajie Wei & Lexin Liu & Di Liu & Xiangning Yan & Minjie Yuan & Lingran Zhang & Ning Zhang & Yan Ren & Feng Chen, 2025. "A TaSnRK1α-TaCAT2 model mediates resistance to Fusarium crown rot by scavenging ROS in common wheat," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57936-x
    DOI: 10.1038/s41467-025-57936-x
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    References listed on IDEAS

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    1. Cong Jiang & Ruonan Hei & Yang Yang & Shijie Zhang & Qinhu Wang & Wei Wang & Qiang Zhang & Min Yan & Gengrui Zhu & Panpan Huang & Huiquan Liu & Jin-Rong Xu, 2020. "An orphan protein of Fusarium graminearum modulates host immunity by mediating proteasomal degradation of TaSnRK1α," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    2. Byung-Wook Yun & Angela Feechan & Minghui Yin & Noor B. B. Saidi & Thierry Le Bihan & Manda Yu & John W. Moore & Jeong-Gu Kang & Eunjung Kwon & Steven H. Spoel & Jacqueline A. Pallas & Gary J. Loake, 2011. "S-nitrosylation of NADPH oxidase regulates cell death in plant immunity," Nature, Nature, vol. 478(7368), pages 264-268, October.
    3. Lei-Jie Jia & Hao-Yu Tang & Wan-Qiu Wang & Ting-Lu Yuan & Wan-Qian Wei & Bo Pang & Xue-Min Gong & Shou-Feng Wang & Yu-Jie Li & Dong Zhang & Wen Liu & Wei-Hua Tang, 2019. "A linear nonribosomal octapeptide from Fusarium graminearum facilitates cell-to-cell invasion of wheat," Nature Communications, Nature, vol. 10(1), pages 1-20, December.
    4. Qiang Xu & Chunlei Tang & Xiaodong Wang & Shutian Sun & Jinren Zhao & Zhensheng Kang & Xiaojie Wang, 2019. "An effector protein of the wheat stripe rust fungus targets chloroplasts and suppresses chloroplast function," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
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