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Functional analysis of the human perivascular subarachnoid space

Author

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  • Per Kristian Eide

    (Oslo University Hospital - Rikshospitalet
    University of Oslo)

  • Geir Ringstad

    (Oslo University Hospital- Rikshospitalet
    Sorlandet Hospital)

Abstract

The human subarachnoid space harbors the cerebrospinal fluid, which flows within a landscape of blood vessels and trabeculae. Functional implications of subarachnoid space anatomy remain far less understood. This study of 75 patients utilizes a cerebrospinal fluid tracer (gadobutrol) and consecutive magnetic resonance imaging to investigate features of early (i.e. within 2-3 h after injection) tracer propagation within the subarachnoid space. There is a time-dependent perivascular pattern of enrichment antegrade along the major cerebral artery trunks; the anterior-, middle-, and posterior cerebral arteries. The correlation between time of first enrichment around arteries and early enrichment in nearby cerebral cortex is significant. These observations suggest the existence of a compartmentalized subarachnoid space, where perivascular ensheathment of arteries facilitates antegrade tracer passage towards brain tissue. Periarterial transport is impaired in subjects with reduced intracranial pressure-volume reserve capacity and in idiopathic normal pressure hydrocephalus patients who also show increased perivascular space size.

Suggested Citation

  • Per Kristian Eide & Geir Ringstad, 2024. "Functional analysis of the human perivascular subarachnoid space," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46329-1
    DOI: 10.1038/s41467-024-46329-1
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