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Plasma neurodegeneration biomarker concentrations associate with glymphatic and meningeal lymphatic measures in neurological disorders

Author

Listed:
  • Per Kristian Eide

    (Oslo University Hospital-Rikshospitalet
    University of Oslo)

  • Aslan Lashkarivand

    (Oslo University Hospital-Rikshospitalet
    University of Oslo)

  • Are Pripp

    (Oslo University Hospital
    Oslo Metropolitan University)

  • Lars Magnus Valnes

    (Oslo University Hospital-Rikshospitalet)

  • Markus Herberg Hovd

    (University of Oslo)

  • Geir Ringstad

    (Oslo University Hospital—Rikshospitalet
    Sorlandet Hospital)

  • Kaj Blennow

    (the Sahlgrenska Academy at the University of Gothenburg
    Sahlgrenska University Hospital)

  • Henrik Zetterberg

    (the Sahlgrenska Academy at the University of Gothenburg
    Sahlgrenska University Hospital
    UCL Institute of Neurology
    UK Dementia Research Institute at UCL)

Abstract

Clearance of neurotoxic brain proteins via cerebrospinal fluid (CSF) to blood has recently emerged to be crucial, and plasma biomarkers of neurodegeneration were newly introduced to predict neurological disease. This study examines in 106 individuals with neurological disorders associations between plasma biomarkers [40 and 42 amino acid-long amyloid-β (Aβ40 and Aβ42), total-tau, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL)] and magnetic resonance imaging measures of CSF-mediated clearance from brain via extra-vascular pathways (proxy of glymphatic function) and CSF-to-blood clearance variables from pharmacokinetic modeling (proxy of meningeal lymphatic egress). We also examine how biomarkers vary during daytime and associate with subjective sleep quality. Plasma concentrations of neurodegeneration markers associate with indices of glymphatic and meningeal lymphatic functions in individual- and disease-specific manners, vary during daytime, but are unaffected by sleep quality. The results suggest that plasma concentrations of neurodegeneration biomarkers associate with measures of glymphatic and meningeal lymphatic function.

Suggested Citation

  • Per Kristian Eide & Aslan Lashkarivand & Are Pripp & Lars Magnus Valnes & Markus Herberg Hovd & Geir Ringstad & Kaj Blennow & Henrik Zetterberg, 2023. "Plasma neurodegeneration biomarker concentrations associate with glymphatic and meningeal lymphatic measures in neurological disorders," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37685-5
    DOI: 10.1038/s41467-023-37685-5
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