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Frequency, kinetics and determinants of viable SARS-CoV-2 in bioaerosols from ambulatory COVID-19 patients infected with the Beta, Delta or Omicron variants

Author

Listed:
  • S. Jaumdally

    (Centre for Lung Infection and Immunity, University of Cape Town Lung Institute
    South African Medical Research Council)

  • M. Tomasicchio

    (Centre for Lung Infection and Immunity, University of Cape Town Lung Institute
    South African Medical Research Council)

  • A. Pooran

    (Centre for Lung Infection and Immunity, University of Cape Town Lung Institute
    South African Medical Research Council)

  • A. Esmail

    (Centre for Lung Infection and Immunity, University of Cape Town Lung Institute
    South African Medical Research Council)

  • A. Kotze

    (Centre for Lung Infection and Immunity, University of Cape Town Lung Institute
    South African Medical Research Council)

  • S. Meier

    (Centre for Lung Infection and Immunity, University of Cape Town Lung Institute
    South African Medical Research Council)

  • L. Wilson

    (Centre for Lung Infection and Immunity, University of Cape Town Lung Institute
    South African Medical Research Council)

  • S. Oelofse

    (Centre for Lung Infection and Immunity, University of Cape Town Lung Institute
    South African Medical Research Council)

  • C. Merwe

    (Centre for Lung Infection and Immunity, University of Cape Town Lung Institute
    South African Medical Research Council)

  • A. Roomaney

    (Centre for Lung Infection and Immunity, University of Cape Town Lung Institute
    South African Medical Research Council)

  • M. Davids

    (Centre for Lung Infection and Immunity, University of Cape Town Lung Institute
    South African Medical Research Council)

  • T. Suliman

    (University of the Western Cape)

  • R. Joseph

    (Wellcome Centre for Infectious Diseases in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town)

  • T. Perumal

    (Centre for Lung Infection and Immunity, University of Cape Town Lung Institute
    South African Medical Research Council)

  • A. Scott

    (Centre for Lung Infection and Immunity, University of Cape Town Lung Institute
    South African Medical Research Council)

  • M. Shaw

    (University of the Western Cape)

  • W. Preiser

    (University of Stellenbosch Tygerberg Campus; Medical Virology, National Health Laboratory Service Tygerberg, Parow)

  • C. Williamson

    (Wellcome Centre for Infectious Diseases in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
    Centre for the AIDS Programme of Research in South Africa (CAPRISA)
    National Health Laboratory Service (NHLS))

  • A. Goga

    (South African Medical Research Council
    University of Pretoria)

  • E. Mayne

    (Faculty of Health Sciences, University of the Witwatersrand
    National Health Laboratory Services
    Faculty of Health Sciences, University of Cape Town)

  • G. Gray

    (South African Medical Research Council)

  • P. Moore

    (Centre for the AIDS Programme of Research in South Africa (CAPRISA)
    National Institute for Communicable Diseases of the National Health Laboratory Service
    School of Pathology, Faculty of Health Sciences, University of the Witwatersrand)

  • A. Sigal

    (Africa Health Research Institute
    University of KwaZulu-Natal
    Max Planck Institute for Infection Biology)

  • J. Limberis

    (Zuckerberg San Francisco General Hospital and Trauma Centre, University of California, San Francisco)

  • J. Metcalfe

    (Zuckerberg San Francisco General Hospital and Trauma Centre, University of California, San Francisco)

  • K. Dheda

    (Centre for Lung Infection and Immunity, University of Cape Town Lung Institute
    South African Medical Research Council
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine)

Abstract

Airborne transmission of SARS-CoV-2 aerosol remains contentious. Importantly, whether cough or breath-generated bioaerosols can harbor viable and replicating virus remains largely unclarified. We performed size-fractionated aerosol sampling (Andersen cascade impactor) and evaluated viral culturability in human cell lines (infectiousness), viral genetics, and host immunity in ambulatory participants with COVID-19. Sixty-one percent (27/44) and 50% (22/44) of participants emitted variant-specific culture-positive aerosols 95%). There is considerable heterogeneity in potential infectiousness i.e., only 29% of participants were probably highly infectious (produced culture-positive aerosols

Suggested Citation

  • S. Jaumdally & M. Tomasicchio & A. Pooran & A. Esmail & A. Kotze & S. Meier & L. Wilson & S. Oelofse & C. Merwe & A. Roomaney & M. Davids & T. Suliman & R. Joseph & T. Perumal & A. Scott & M. Shaw & W, 2024. "Frequency, kinetics and determinants of viable SARS-CoV-2 in bioaerosols from ambulatory COVID-19 patients infected with the Beta, Delta or Omicron variants," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45400-1
    DOI: 10.1038/s41467-024-45400-1
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    References listed on IDEAS

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    1. Sydney R. Stein & Sabrina C. Ramelli & Alison Grazioli & Joon-Yong Chung & Manmeet Singh & Claude Kwe Yinda & Clayton W. Winkler & Junfeng Sun & James M. Dickey & Kris Ylaya & Sung Hee Ko & Andrew P. , 2022. "SARS-CoV-2 infection and persistence in the human body and brain at autopsy," Nature, Nature, vol. 612(7941), pages 758-763, December.
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