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Fully implanted battery-free high power platform for chronic spinal and muscular functional electrical stimulation

Author

Listed:
  • Alex Burton

    (University of Arizona)

  • Zhong Wang

    (Northwestern University)

  • Dan Song

    (Northwestern University)

  • Sam Tran

    (Northwestern University)

  • Jessica Hanna

    (University of Arizona)

  • Dhrubo Ahmad

    (University of Arizona)

  • Jakob Bakall

    (University of Arizona)

  • David Clausen

    (University of Arizona)

  • Jerry Anderson

    (University of Arizona)

  • Roberto Peralta

    (University of Arizona)

  • Kirtana Sandepudi

    (Northwestern University)

  • Alex Benedetto

    (Northwestern University)

  • Ethan Yang

    (Northwestern University)

  • Diya Basrai

    (Northwestern University)

  • Lee E. Miller

    (Northwestern University
    Northwestern University
    Northwestern University
    Northwestern University)

  • Matthew C. Tresch

    (Northwestern University
    Northwestern University
    Shirley Ryan AbilityLab)

  • Philipp Gutruf

    (University of Arizona
    University of Arizona
    University of Arizona)

Abstract

Electrical stimulation of the neuromuscular system holds promise for both scientific and therapeutic biomedical applications. Supplying and maintaining the power necessary to drive stimulation chronically is a fundamental challenge in these applications, especially when high voltages or currents are required. Wireless systems, in which energy is supplied through near field power transfer, could eliminate complications caused by battery packs or external connections, but currently do not provide the harvested power and voltages required for applications such as muscle stimulation. Here, we introduce a passive resonator optimized power transfer design that overcomes these limitations, enabling voltage compliances of ± 20 V and power over 300 mW at device volumes of 0.2 cm2, thereby improving power transfer 500% over previous systems. We show that this improved performance enables multichannel, biphasic, current-controlled operation at clinically relevant voltage and current ranges with digital control and telemetry in freely behaving animals. Preliminary chronic results indicate that implanted devices remain operational over 6 weeks in both intact and spinal cord injured rats and are capable of producing fine control of spinal and muscle stimulation.

Suggested Citation

  • Alex Burton & Zhong Wang & Dan Song & Sam Tran & Jessica Hanna & Dhrubo Ahmad & Jakob Bakall & David Clausen & Jerry Anderson & Roberto Peralta & Kirtana Sandepudi & Alex Benedetto & Ethan Yang & Diya, 2023. "Fully implanted battery-free high power platform for chronic spinal and muscular functional electrical stimulation," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43669-2
    DOI: 10.1038/s41467-023-43669-2
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    References listed on IDEAS

    as
    1. Philipp Gutruf & Rose T. Yin & K. Benjamin Lee & Jokubas Ausra & Jaclyn A. Brennan & Yun Qiao & Zhaoqian Xie & Roberto Peralta & Olivia Talarico & Alejandro Murillo & Sheena W. Chen & John P. Leshock , 2019. "Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    2. Sheng Xu & Yihui Zhang & Jiung Cho & Juhwan Lee & Xian Huang & Lin Jia & Jonathan A. Fan & Yewang Su & Jessica Su & Huigang Zhang & Huanyu Cheng & Bingwei Lu & Cunjiang Yu & Chi Chuang & Tae-il Kim & , 2013. "Stretchable batteries with self-similar serpentine interconnects and integrated wireless recharging systems," Nature Communications, Nature, vol. 4(1), pages 1-8, June.
    3. Matjaz Rozman & Michael Fernando & Bamidele Adebisi & Khaled M. Rabie & Rupak Kharel & Augustine Ikpehai & Haris Gacanin, 2017. "Combined Conformal Strongly-Coupled Magnetic Resonance for Efficient Wireless Power Transfer," Energies, MDPI, vol. 10(4), pages 1-18, April.
    4. Le Cai & Alex Burton & David A. Gonzales & Kevin Albert Kasper & Amirhossein Azami & Roberto Peralta & Megan Johnson & Jakob A. Bakall & Efren Barron Villalobos & Ethan C. Ross & John A. Szivek & Davi, 2021. "Osseosurface electronics—thin, wireless, battery-free and multimodal musculoskeletal biointerfaces," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    5. Marco Bonizzato & Galyna Pidpruzhnykova & Jack DiGiovanna & Polina Shkorbatova & Natalia Pavlova & Silvestro Micera & Grégoire Courtine, 2018. "Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
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