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Sustainable production of dopamine hydrochloride from softwood lignin

Author

Listed:
  • Lin Dong

    (Nanjing Forestry University
    East China University of Science and Technology)

  • Yanqin Wang

    (East China University of Science and Technology)

  • Yuguo Dong

    (Nanjing Forestry University)

  • Yin Zhang

    (Nanjing Forestry University)

  • Mingzhu Pan

    (Nanjing Forestry University)

  • Xiaohui Liu

    (East China University of Science and Technology)

  • Xiaoli Gu

    (Nanjing Forestry University)

  • Markus Antonietti

    (Max-Planck Institute of Colloids and Interfaces, Research Campus Golm)

  • Zupeng Chen

    (Nanjing Forestry University
    University of Rostock)

Abstract

Dopamine is not only a widely used commodity pharmaceutical for treating neurological diseases but also a highly attractive base for advanced carbon materials. Lignin, the waste from the lignocellulosic biomass industry, is the richest source of renewable aromatics on earth. Efficient production of dopamine direct from lignin is a highly desirable target but extremely challenging. Here, we report an innovative strategy for the sustainable production of dopamine hydrochloride from softwood lignin with a mass yield of 6.4 wt.%. Significantly, the solid dopamine hydrochloride is obtained by a simple filtration process in purity of 98.0%, which avoids the tedious separation and purification steps. The approach begins with the acid-catalyzed depolymerization, followed by deprotection, hydrogen-borrowing amination, and hydrolysis of methoxy group, transforming lignin into dopamine hydrochloride. The technical economic analysis predicts that this process is an economically competitive production process. This study fulfills the unexplored potential of dopamine hydrochloride synthesis from lignin.

Suggested Citation

  • Lin Dong & Yanqin Wang & Yuguo Dong & Yin Zhang & Mingzhu Pan & Xiaohui Liu & Xiaoli Gu & Markus Antonietti & Zupeng Chen, 2023. "Sustainable production of dopamine hydrochloride from softwood lignin," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40702-2
    DOI: 10.1038/s41467-023-40702-2
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    References listed on IDEAS

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    1. Qinglei Meng & Jiang Yan & Ruizhi Wu & Huizhen Liu & Yang Sun & NingNing Wu & Junfeng Xiang & Lirong Zheng & Jing Zhang & Buxing Han, 2021. "Sustainable production of benzene from lignin," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
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    Cited by:

    1. Li Xu & Meifang Cao & Jiefeng Zhou & Yuxia Pang & Zhixian Li & Dongjie Yang & Shao-Yuan Leu & Hongming Lou & Xuejun Pan & Xueqing Qiu, 2024. "Aqueous amine enables sustainable monosaccharide, monophenol, and pyridine base coproduction in lignocellulosic biorefineries," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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