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Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types

Author

Listed:
  • Stan L. W. Driessens

    (Vrije Universiteit Amsterdam)

  • Anna A. Galakhova

    (Vrije Universiteit Amsterdam)

  • Djai B. Heyer

    (Vrije Universiteit Amsterdam)

  • Isabel J. Pieterse

    (Vrije Universiteit Amsterdam)

  • René Wilbers

    (Vrije Universiteit Amsterdam)

  • Eline J. Mertens

    (Vrije Universiteit Amsterdam)

  • Femke Waleboer

    (Vrije Universiteit Amsterdam)

  • Tim S. Heistek

    (Vrije Universiteit Amsterdam)

  • Loet Coenen

    (Vrije Universiteit Amsterdam)

  • Julia R. Meijer

    (Vrije Universiteit Amsterdam)

  • Sander Idema

    (Amsterdam UMC Location Vrije Universiteit Amsterdam)

  • Philip C. Witt Hamer

    (Amsterdam UMC Location Vrije Universiteit Amsterdam)

  • David P. Noske

    (Amsterdam UMC Location Vrije Universiteit Amsterdam)

  • Christiaan P. J. Kock

    (Vrije Universiteit Amsterdam)

  • Brian R. Lee

    (Allen Institute for Brain Science)

  • Kimberly Smith

    (Allen Institute for Brain Science)

  • Jonathan T. Ting

    (Allen Institute for Brain Science)

  • Ed S. Lein

    (Allen Institute for Brain Science)

  • Huibert D. Mansvelder

    (Vrije Universiteit Amsterdam)

  • Natalia A. Goriounova

    (Vrije Universiteit Amsterdam)

Abstract

GWAS have identified numerous genes associated with human cognition but their cell type expression profiles in the human brain are unknown. These genes overlap with human accelerated regions (HARs) implicated in human brain evolution and might act on the same biological processes. Here, we investigated whether these gene sets are expressed in adult human cortical neurons, and how their expression relates to neuronal function and structure. We find that these gene sets are preferentially expressed in L3 pyramidal neurons in middle temporal gyrus (MTG). Furthermore, neurons with higher expression had larger total dendritic length (TDL) and faster action potential (AP) kinetics, properties previously linked to intelligence. We identify a subset of genes associated with TDL or AP kinetics with predominantly synaptic functions and high abundance of HARs.

Suggested Citation

  • Stan L. W. Driessens & Anna A. Galakhova & Djai B. Heyer & Isabel J. Pieterse & René Wilbers & Eline J. Mertens & Femke Waleboer & Tim S. Heistek & Loet Coenen & Julia R. Meijer & Sander Idema & Phili, 2023. "Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39946-9
    DOI: 10.1038/s41467-023-39946-9
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    References listed on IDEAS

    as
    1. Rebecca D. Hodge & Trygve E. Bakken & Jeremy A. Miller & Kimberly A. Smith & Eliza R. Barkan & Lucas T. Graybuck & Jennie L. Close & Brian Long & Nelson Johansen & Osnat Penn & Zizhen Yao & Jeroen Egg, 2019. "Conserved cell types with divergent features in human versus mouse cortex," Nature, Nature, vol. 573(7772), pages 61-68, September.
    2. Joshua Obermayer & Tim S. Heistek & Amber Kerkhofs & Natalia A. Goriounova & Tim Kroon & Johannes C. Baayen & Sander Idema & Guilherme Testa-Silva & Jonathan J. Couey & Huibert D. Mansvelder, 2018. "Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    3. Jim Berg & Staci A. Sorensen & Jonathan T. Ting & Jeremy A. Miller & Thomas Chartrand & Anatoly Buchin & Trygve E. Bakken & Agata Budzillo & Nick Dee & Song-Lin Ding & Nathan W. Gouwens & Rebecca D. H, 2021. "Human neocortical expansion involves glutamatergic neuron diversification," Nature, Nature, vol. 598(7879), pages 151-158, October.
    4. Yongbin Wei & Siemon C. de Lange & Lianne H. Scholtens & Kyoko Watanabe & Dirk Jan Ardesch & Philip R. Jansen & Jeanne E. Savage & Longchuan Li & Todd M. Preuss & James K. Rilling & Danielle Posthuma , 2019. "Genetic mapping and evolutionary analysis of human-expanded cognitive networks," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
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