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Intrinsic timescales in the visual cortex change with selective attention and reflect spatial connectivity

Author

Listed:
  • Roxana Zeraati

    (University of Tübingen
    Max Planck Institute for Biological Cybernetics)

  • Yan-Liang Shi

    (Cold Spring Harbor Laboratory
    Princeton University)

  • Nicholas A. Steinmetz

    (University of Washington)

  • Marc A. Gieselmann

    (Newcastle University)

  • Alexander Thiele

    (Newcastle University)

  • Tirin Moore

    (Stanford University)

  • Anna Levina

    (Max Planck Institute for Biological Cybernetics
    University of Tübingen
    Bernstein Center for Computational Neuroscience Tübingen)

  • Tatiana A. Engel

    (Cold Spring Harbor Laboratory
    Princeton University)

Abstract

Intrinsic timescales characterize dynamics of endogenous fluctuations in neural activity. Variation of intrinsic timescales across the neocortex reflects functional specialization of cortical areas, but less is known about how intrinsic timescales change during cognitive tasks. We measured intrinsic timescales of local spiking activity within columns of area V4 in male monkeys performing spatial attention tasks. The ongoing spiking activity unfolded across at least two distinct timescales, fast and slow. The slow timescale increased when monkeys attended to the receptive fields location and correlated with reaction times. By evaluating predictions of several network models, we found that spatiotemporal correlations in V4 activity were best explained by the model in which multiple timescales arise from recurrent interactions shaped by spatially arranged connectivity, and attentional modulation of timescales results from an increase in the efficacy of recurrent interactions. Our results suggest that multiple timescales may arise from the spatial connectivity in the visual cortex and flexibly change with the cognitive state due to dynamic effective interactions between neurons.

Suggested Citation

  • Roxana Zeraati & Yan-Liang Shi & Nicholas A. Steinmetz & Marc A. Gieselmann & Alexander Thiele & Tirin Moore & Anna Levina & Tatiana A. Engel, 2023. "Intrinsic timescales in the visual cortex change with selective attention and reflect spatial connectivity," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37613-7
    DOI: 10.1038/s41467-023-37613-7
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    References listed on IDEAS

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