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Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice

Author

Listed:
  • Young Hee Lee

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Yu-Been Kim

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Kyu Sik Kim

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Mirae Jang

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Ha Young Song

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Sang-Ho Jung

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Dong-Soo Ha

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Joon Seok Park

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Jaegeon Lee

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Kyung Min Kim

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Deok-Hyeon Cheon

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Inhyeok Baek

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Min-Gi Shin

    (Ajou University School of Medicine)

  • Eun Jeong Lee

    (Ajou University School of Medicine)

  • Sang Jeong Kim

    (Seoul National University College of Medicine
    Seoul National University College of Medicine
    Seoul National University College of Medicine
    Seoul National University)

  • Hyung Jin Choi

    (Seoul National University College of Medicine
    Seoul National University College of Medicine
    Seoul National University College of Medicine
    Seoul National University)

Abstract

For survival, it is crucial for eating behaviours to be sequenced through two distinct seeking and consummatory phases. Heterogeneous lateral hypothalamus (LH) neurons are known to regulate motivated behaviours, yet which subpopulation drives food seeking and consummatory behaviours have not been fully addressed. Here, in male mice, fibre photometry recordings demonstrated that LH leptin receptor (LepR) neurons are correlated explicitly in both voluntary seeking and consummatory behaviours. Further, micro-endoscope recording of the LHLepR neurons demonstrated that one subpopulation is time-locked to seeking behaviours and the other subpopulation time-locked to consummatory behaviours. Seeking or consummatory phase specific paradigm revealed that activation of LHLepR neurons promotes seeking or consummatory behaviours and inhibition of LHLepR neurons reduces consummatory behaviours. The activity of LHLepR neurons was increased via Neuropeptide Y (NPY) which acted as a tonic permissive gate signal. Our results identify neural populations that mediate seeking and consummatory behaviours and may lead to therapeutic targets for maladaptive food seeking and consummatory behaviours.

Suggested Citation

  • Young Hee Lee & Yu-Been Kim & Kyu Sik Kim & Mirae Jang & Ha Young Song & Sang-Ho Jung & Dong-Soo Ha & Joon Seok Park & Jaegeon Lee & Kyung Min Kim & Deok-Hyeon Cheon & Inhyeok Baek & Min-Gi Shin & Eun, 2023. "Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37044-4
    DOI: 10.1038/s41467-023-37044-4
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