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An interactive murine single-cell atlas of the lung responses to radiation injury

Author

Listed:
  • Sandra Curras-Alonso

    (Sorbonne Universite, PSL University
    University Paris-Saclay, PSL University, Centre Universitaire)

  • Juliette Soulier

    (Sorbonne Universite, PSL University
    University Paris-Saclay, PSL University, Centre Universitaire)

  • Thomas Defard

    (PSL University
    PSL University
    INSERM, U900
    Université Paris Cité)

  • Christian Weber

    (Université Paris Cité)

  • Sophie Heinrich

    (University Paris-Saclay, PSL University, Centre Universitaire)

  • Hugo Laporte

    (Sorbonne Universite, PSL University
    University Paris-Saclay, PSL University, Centre Universitaire)

  • Sophie Leboucher

    (University Paris-Saclay, PSL University, Centre Universitaire)

  • Sonia Lameiras

    (Institut Curie Genomics of Excellence (ICGex) Platform)

  • Marie Dutreix

    (University Paris-Saclay, PSL University, Centre Universitaire)

  • Vincent Favaudon

    (University Paris-Saclay, PSL University, Centre Universitaire)

  • Florian Massip

    (PSL University
    PSL University
    INSERM, U900)

  • Thomas Walter

    (PSL University
    PSL University
    INSERM, U900)

  • Florian Mueller

    (Université Paris Cité)

  • José-Arturo Londoño-Vallejo

    (Sorbonne Universite, PSL University
    University Paris-Saclay, PSL University, Centre Universitaire)

  • Charles Fouillade

    (University Paris-Saclay, PSL University, Centre Universitaire)

Abstract

Radiation Induced Lung Injury (RILI) is one of the main limiting factors of thorax irradiation, which can induce acute pneumonitis as well as pulmonary fibrosis, the latter being a life-threatening condition. The order of cellular and molecular events in the progression towards fibrosis is key to the physiopathogenesis of the disease, yet their coordination in space and time remains largely unexplored. Here, we present an interactive murine single cell atlas of the lung response to irradiation, generated from C57BL6/J female mice. This tool opens the door for exploration of the spatio-temporal dynamics of the mechanisms that lead to radiation-induced pulmonary fibrosis. It depicts with unprecedented detail cell type-specific radiation-induced responses associated with either lung regeneration or the failure thereof. A better understanding of the mechanisms leading to lung fibrosis will help finding new therapeutic options that could improve patients’ quality of life.

Suggested Citation

  • Sandra Curras-Alonso & Juliette Soulier & Thomas Defard & Christian Weber & Sophie Heinrich & Hugo Laporte & Sophie Leboucher & Sonia Lameiras & Marie Dutreix & Vincent Favaudon & Florian Massip & Tho, 2023. "An interactive murine single-cell atlas of the lung responses to radiation injury," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38134-z
    DOI: 10.1038/s41467-023-38134-z
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