IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-35518-5.html
   My bibliography  Save this article

St18 specifies globus pallidus projection neuron identity in MGE lineage

Author

Listed:
  • Luke F. Nunnelly

    (Columbia University Irving Medical Center)

  • Melissa Campbell

    (Columbia University Irving Medical Center)

  • Dylan I. Lee

    (Columbia University Irving Medical Center)

  • Patrick Dummer

    (Columbia University Irving Medical Center)

  • Guoqiang Gu

    (Vanderbilt University School of Medicine)

  • Vilas Menon

    (Columbia University Irving Medical Center)

  • Edmund Au

    (Columbia University Irving Medical Center
    Columbia University Irving Medical Center
    Columbia University Irving Medical Center)

Abstract

The medial ganglionic eminence (MGE) produces both locally-projecting interneurons, which migrate long distances to structures such as the cortex as well as projection neurons that occupy subcortical nuclei. Little is known about what regulates the migratory behavior and axonal projections of these two broad classes of neurons. We find that St18 regulates the migration and morphology of MGE neurons in vitro. Further, genetic loss-of-function of St18 in mice reveals a reduction in projection neurons of the globus pallidus pars externa. St18 functions by influencing cell fate in MGE lineages as we observe a large expansion of nascent cortical interneurons at the expense of putative GPe neurons in St18 null embryos. Downstream of St18, we identified Cbx7, a component of Polycomb repressor complex 1, and find that it is essential for projection neuron-like migration but not morphology. Thus, we identify St18 as a key regulator of projection neuron vs. interneuron identity.

Suggested Citation

  • Luke F. Nunnelly & Melissa Campbell & Dylan I. Lee & Patrick Dummer & Guoqiang Gu & Vilas Menon & Edmund Au, 2022. "St18 specifies globus pallidus projection neuron identity in MGE lineage," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35518-5
    DOI: 10.1038/s41467-022-35518-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-35518-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-35518-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ruchi Malik & Emily Ling-Lin Pai & Anna N Rubin & April M Stafford & Kartik Angara & Petros Minasi & John L. Rubenstein & Vikaas S Sohal & Daniel Vogt, 2019. "Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    2. Julian Ik-Tsen Heng & Laurent Nguyen & Diogo S. Castro & Céline Zimmer & Hendrik Wildner & Olivier Armant & Dorota Skowronska-Krawczyk & Francesco Bedogni & Jean-Marc Matter & Robert Hevner & François, 2008. "Neurogenin 2 controls cortical neuron migration through regulation of Rnd2," Nature, Nature, vol. 455(7209), pages 114-118, September.
    3. Moritz Mall & Michael S. Kareta & Soham Chanda & Henrik Ahlenius & Nicholas Perotti & Bo Zhou & Sarah D. Grieder & Xuecai Ge & Sienna Drake & Cheen Euong Ang & Brandon M. Walker & Thomas Vierbuchen & , 2017. "Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates," Nature, Nature, vol. 544(7649), pages 245-249, April.
    4. Fong Kuan Wong & Kinga Bercsenyi & Varun Sreenivasan & Adrián Portalés & Marian Fernández-Otero & Oscar Marín, 2018. "Pyramidal cell regulation of interneuron survival sculpts cortical networks," Nature, Nature, vol. 557(7707), pages 668-673, May.
    5. Christian Mayer & Christoph Hafemeister & Rachel C. Bandler & Robert Machold & Renata Batista Brito & Xavier Jaglin & Kathryn Allaway & Andrew Butler & Gord Fishell & Rahul Satija, 2018. "Developmental diversification of cortical inhibitory interneurons," Nature, Nature, vol. 555(7697), pages 457-462, March.
    6. Derek G. Southwell & Mercedes F. Paredes & Rui P. Galvao & Daniel L. Jones & Robert C. Froemke & Joy Y. Sebe & Clara Alfaro-Cervello & Yunshuo Tang & Jose M. Garcia-Verdugo & John L. Rubenstein & Scot, 2012. "Intrinsically determined cell death of developing cortical interneurons," Nature, Nature, vol. 491(7422), pages 109-113, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Li-Pao Fang & Na Zhao & Laura C. Caudal & Hsin-Fang Chang & Renping Zhao & Ching-Hsin Lin & Nadine Hainz & Carola Meier & Bernhard Bettler & Wenhui Huang & Anja Scheller & Frank Kirchhoff & Xianshu Ba, 2022. "Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Chuan Gao & Nan Wang & Xiuqing Guo & Julie T Ziegler & Kent D Taylor & Anny H Xiang & Yang Hai & Steven J Kridel & Jerry L Nadler & Fouad Kandeel & Leslie J Raffel & Yii-Der I Chen & Jill M Norris & J, 2015. "A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS)," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-17, November.
    3. Lu, Li & Norder, Kurt A. & Sawhney, Aman & Emich, Kyle J., 2023. "Setting the programmatic agenda: A comprehensive bibliometric overview of team mechanism research," Journal of Business Research, Elsevier, vol. 154(C).
    4. Gintautas Vainorius & Maria Novatchkova & Georg Michlits & Juliane Christina Baar & Cecilia Raupach & Joonsun Lee & Ramesh Yelagandula & Marius Wernig & Ulrich Elling, 2023. "Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Maria E. Monberg & Heather Geiger & Jaewon J. Lee & Roshan Sharma & Alexander Semaan & Vincent Bernard & Justin Wong & Fang Wang & Shaoheng Liang & Daniel B. Swartzlander & Bret M. Stephens & Matthew , 2022. "Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Jia-Ru Wei & Zhao-Zhe Hao & Chuan Xu & Mengyao Huang & Lei Tang & Nana Xu & Ruifeng Liu & Yuhui Shen & Sarah A. Teichmann & Zhichao Miao & Sheng Liu, 2022. "Identification of visual cortex cell types and species differences using single-cell RNA sequencing," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    7. Ravneet Jaura & Ssu-Yu Yeh & Kaitlin N. Montanera & Alyssa Ialongo & Zobia Anwar & Yiming Lu & Kavindu Puwakdandawa & Ho Sung Rhee, 2022. "Extended intergenic DNA contributes to neuron-specific expression of neighboring genes in the mammalian nervous system," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    8. David Morizet & Isabelle Foucher & Alessandro Alunni & Laure Bally-Cuif, 2024. "Reconstruction of macroglia and adult neurogenesis evolution through cross-species single-cell transcriptomic analyses," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    9. Zeinab Asgarian & Marcio Guiomar Oliveira & Agata Stryjewska & Ioannis Maragkos & Anna Noren Rubin & Lorenza Magno & Vassilis Pachnis & Mohammadmersad Ghorbani & Scott Wayne Hiebert & Myrto Denaxa & N, 2022. "MTG8 interacts with LHX6 to specify cortical interneuron subtype identity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    10. Wendy Xueyi Wang & Julie L. Lefebvre, 2022. "Morphological pseudotime ordering and fate mapping reveal diversification of cerebellar inhibitory interneurons," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    11. Chieh Lin & Jun Ding & Ziv Bar-Joseph, 2020. "Inferring TF activation order in time series scRNA-Seq studies," PLOS Computational Biology, Public Library of Science, vol. 16(2), pages 1-19, February.
    12. Christopher T. Rhodes & Joyce J. Thompson & Apratim Mitra & Dhanya Asokumar & Dongjin R. Lee & Daniel J. Lee & Yajun Zhang & Eva Jason & Ryan K. Dale & Pedro P. Rocha & Timothy J. Petros, 2022. "An epigenome atlas of neural progenitors within the embryonic mouse forebrain," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    13. Norder, Kurt & Emich, Kyle & Kanar, Adam & Sawhney, Aman & Behrend, Tara S., 2022. "A house divided: A multilevel bibliometric review of the job search literature 1973–2020," Journal of Business Research, Elsevier, vol. 151(C), pages 100-117.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35518-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.