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MTG8 interacts with LHX6 to specify cortical interneuron subtype identity

Author

Listed:
  • Zeinab Asgarian

    (University College London)

  • Marcio Guiomar Oliveira

    (University College London)

  • Agata Stryjewska

    (University College London)

  • Ioannis Maragkos

    (Biomedical Sciences Research Center “Alexander Fleming”)

  • Anna Noren Rubin

    (University College London)

  • Lorenza Magno

    (University College London)

  • Vassilis Pachnis

    (The Francis Crick Institute)

  • Mohammadmersad Ghorbani

    (University of Southampton, Southampton General Hospital
    Sidra Medicine)

  • Scott Wayne Hiebert

    (Vanderbilt University School of Medicine)

  • Myrto Denaxa

    (Biomedical Sciences Research Center “Alexander Fleming”)

  • Nicoletta Kessaris

    (University College London)

Abstract

Cortical interneurons originating in the embryonic medial ganglionic eminence (MGE) diverge into a range of different subtypes found in the adult mouse cerebral cortex. The mechanisms underlying this divergence and the timing when subtype identity is set up remain unclear. We identify the highly conserved transcriptional co-factor MTG8 as being pivotal in the development of a large subset of MGE cortical interneurons that co-expresses Somatostatin (SST) and Neuropeptide Y (NPY). MTG8 interacts with the pan-MGE transcription factor LHX6 and together the two factors are sufficient to promote expression of critical cortical interneuron subtype identity genes. The SST-NPY cortical interneuron fate is initiated early, well before interneurons migrate into the cortex, demonstrating an early onset specification program. Our findings suggest that transcriptional co-factors and modifiers of generic lineage specification programs may hold the key to the emergence of cortical interneuron heterogeneity from the embryonic telencephalic germinal zones.

Suggested Citation

  • Zeinab Asgarian & Marcio Guiomar Oliveira & Agata Stryjewska & Ioannis Maragkos & Anna Noren Rubin & Lorenza Magno & Vassilis Pachnis & Mohammadmersad Ghorbani & Scott Wayne Hiebert & Myrto Denaxa & N, 2022. "MTG8 interacts with LHX6 to specify cortical interneuron subtype identity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32898-6
    DOI: 10.1038/s41467-022-32898-6
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