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Proteogenomic characterization of MiT family translocation renal cell carcinoma

Author

Listed:
  • Yuanyuan Qu

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University
    Shanghai Medical College, Shanghai Genitourinary Cancer Institute)

  • Xiaohui Wu

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University)

  • Aihetaimujiang Anwaier

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University
    Shanghai Medical College, Shanghai Genitourinary Cancer Institute)

  • Jinwen Feng

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University)

  • Wenhao Xu

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University
    Shanghai Medical College, Shanghai Genitourinary Cancer Institute)

  • Xiaoru Pei

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University)

  • Yu Zhu

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University
    Shanghai Medical College, Shanghai Genitourinary Cancer Institute)

  • Yang Liu

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University)

  • Lin Bai

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University)

  • Guojian Yang

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University)

  • Xi Tian

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University
    Shanghai Medical College, Shanghai Genitourinary Cancer Institute)

  • Jiaqi Su

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University
    Shanghai Medical College, Shanghai Genitourinary Cancer Institute)

  • Guo-Hai Shi

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University
    Shanghai Medical College, Shanghai Genitourinary Cancer Institute)

  • Da-Long Cao

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University
    Shanghai Medical College, Shanghai Genitourinary Cancer Institute)

  • Fujiang Xu

    (The Affiliated Hospital of Southwest Medical University)

  • Yue Wang

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University
    Shanghai Medical College, Shanghai Genitourinary Cancer Institute)

  • Hua-Lei Gan

    (Shanghai Medical College, Shanghai Genitourinary Cancer Institute
    Fudan University Shanghai Cancer Center)

  • Shujuan Ni

    (Shanghai Medical College, Shanghai Genitourinary Cancer Institute
    Fudan University Shanghai Cancer Center)

  • Meng-Hong Sun

    (Shanghai Medical College, Shanghai Genitourinary Cancer Institute
    Fudan University Shanghai Cancer Center)

  • Jian-Yuan Zhao

    (Shanghai Jiao Tong University School of Medicine)

  • Hailiang Zhang

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University
    Shanghai Medical College, Shanghai Genitourinary Cancer Institute)

  • Dingwei Ye

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University
    Shanghai Medical College, Shanghai Genitourinary Cancer Institute)

  • Chen Ding

    (Institute of Biomedical Sciences, and Human Phenome Institute, Fudan University)

Abstract

Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) is a rare type of kidney cancer, which is not well characterized. Here we show the comprehensive proteogenomic analysis of tRCC tumors and normal adjacent tissues to elucidate the molecular landscape of this disease. Our study reveals that defective DNA repair plays an important role in tRCC carcinogenesis and progression. Metabolic processes are markedly dysregulated at both the mRNA and protein levels. Proteomic and phosphoproteome data identify mTOR signaling pathway as a potential therapeutic target. Moreover, molecular subtyping and immune infiltration analysis characterize the inter-tumoral heterogeneity of tRCC. Multi-omic integration reveals the dysregulation of cellular processes affected by genomic alterations, including oxidative phosphorylation, autophagy, transcription factor activity, and proteasome function. This study represents a comprehensive proteogenomic analysis of tRCC, providing valuable insights into its biological mechanisms, disease diagnosis, and prognostication.

Suggested Citation

  • Yuanyuan Qu & Xiaohui Wu & Aihetaimujiang Anwaier & Jinwen Feng & Wenhao Xu & Xiaoru Pei & Yu Zhu & Yang Liu & Lin Bai & Guojian Yang & Xi Tian & Jiaqi Su & Guo-Hai Shi & Da-Long Cao & Fujiang Xu & Yu, 2022. "Proteogenomic characterization of MiT family translocation renal cell carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34460-w
    DOI: 10.1038/s41467-022-34460-w
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