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Mutational heterogeneity in cancer and the search for new cancer-associated genes

Author

Listed:
  • Michael S. Lawrence

    (The Broad Institute of MIT and Harvard)

  • Petar Stojanov

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute)

  • Paz Polak

    (The Broad Institute of MIT and Harvard
    Harvard Medical School
    Brigham and Women's Hospital)

  • Gregory V. Kryukov

    (The Broad Institute of MIT and Harvard
    Harvard Medical School
    Brigham and Women's Hospital)

  • Kristian Cibulskis

    (The Broad Institute of MIT and Harvard)

  • Andrey Sivachenko

    (The Broad Institute of MIT and Harvard)

  • Scott L. Carter

    (The Broad Institute of MIT and Harvard)

  • Chip Stewart

    (The Broad Institute of MIT and Harvard)

  • Craig H. Mermel

    (The Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Steven A. Roberts

    (Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Durham, North Carolina 27709, USA)

  • Adam Kiezun

    (The Broad Institute of MIT and Harvard)

  • Peter S. Hammerman

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute)

  • Aaron McKenna

    (The Broad Institute of MIT and Harvard
    Genome Sciences, University of Washington)

  • Yotam Drier

    (The Broad Institute of MIT and Harvard
    Harvard Medical School
    Massachusetts General Hospital
    Howard Hughes Medical Institute)

  • Lihua Zou

    (The Broad Institute of MIT and Harvard)

  • Alex H. Ramos

    (The Broad Institute of MIT and Harvard)

  • Trevor J. Pugh

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Nicolas Stransky

    (The Broad Institute of MIT and Harvard
    Blueprint Medicines)

  • Elena Helman

    (The Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

  • Jaegil Kim

    (The Broad Institute of MIT and Harvard)

  • Carrie Sougnez

    (The Broad Institute of MIT and Harvard)

  • Lauren Ambrogio

    (The Broad Institute of MIT and Harvard)

  • Elizabeth Nickerson

    (The Broad Institute of MIT and Harvard)

  • Erica Shefler

    (The Broad Institute of MIT and Harvard)

  • Maria L. Cortés

    (The Broad Institute of MIT and Harvard)

  • Daniel Auclair

    (The Broad Institute of MIT and Harvard)

  • Gordon Saksena

    (The Broad Institute of MIT and Harvard)

  • Douglas Voet

    (The Broad Institute of MIT and Harvard)

  • Michael Noble

    (The Broad Institute of MIT and Harvard)

  • Daniel DiCara

    (The Broad Institute of MIT and Harvard)

  • Pei Lin

    (The Broad Institute of MIT and Harvard)

  • Lee Lichtenstein

    (The Broad Institute of MIT and Harvard)

  • David I. Heiman

    (The Broad Institute of MIT and Harvard)

  • Timothy Fennell

    (The Broad Institute of MIT and Harvard)

  • Marcin Imielinski

    (The Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Bryan Hernandez

    (The Broad Institute of MIT and Harvard)

  • Eran Hodis

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute)

  • Sylvan Baca

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute)

  • Austin M. Dulak

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute)

  • Jens Lohr

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute)

  • Dan-Avi Landau

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute
    Yale Cancer Center)

  • Catherine J. Wu

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Jorge Melendez-Zajgla

    (Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico)

  • Alfredo Hidalgo-Miranda

    (Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico)

  • Amnon Koren

    (The Broad Institute of MIT and Harvard
    Harvard Medical School)

  • Steven A. McCarroll

    (The Broad Institute of MIT and Harvard
    Harvard Medical School)

  • Jaume Mora

    (Hospital Sant Joan de Déu, Barcelona 08950, Spain)

  • Ryan S. Lee

    (Dana-Farber Cancer Institute
    Harvard Medical School
    Boston Children’s Hospital)

  • Brian Crompton

    (Dana-Farber Cancer Institute
    Boston Children’s Hospital)

  • Robert Onofrio

    (The Broad Institute of MIT and Harvard)

  • Melissa Parkin

    (The Broad Institute of MIT and Harvard)

  • Wendy Winckler

    (The Broad Institute of MIT and Harvard)

  • Kristin Ardlie

    (The Broad Institute of MIT and Harvard)

  • Stacey B. Gabriel

    (The Broad Institute of MIT and Harvard)

  • Charles W. M. Roberts

    (Dana-Farber Cancer Institute
    Harvard Medical School
    Boston Children’s Hospital)

  • Jaclyn A. Biegel

    (Children’s Hospital)

  • Kimberly Stegmaier

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute
    Boston Children’s Hospital)

  • Adam J. Bass

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Levi A. Garraway

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Matthew Meyerson

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Todd R. Golub

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute
    Harvard Medical School
    Howard Hughes Medical Institute)

  • Dmitry A. Gordenin

    (Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Durham, North Carolina 27709, USA)

  • Shamil Sunyaev

    (The Broad Institute of MIT and Harvard
    Harvard Medical School
    Brigham and Women's Hospital)

  • Eric S. Lander

    (The Broad Institute of MIT and Harvard
    Harvard Medical School
    Massachusetts Institute of Technology)

  • Gad Getz

    (The Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

Abstract

As the sample size in cancer genome studies increases, the list of genes identified as significantly mutated is likely to include more false positives; here, this problem is identified as stemming largely from mutation heterogeneity, and a new analytical methodology designed to overcome this problem is described.

Suggested Citation

  • Michael S. Lawrence & Petar Stojanov & Paz Polak & Gregory V. Kryukov & Kristian Cibulskis & Andrey Sivachenko & Scott L. Carter & Chip Stewart & Craig H. Mermel & Steven A. Roberts & Adam Kiezun & Pe, 2013. "Mutational heterogeneity in cancer and the search for new cancer-associated genes," Nature, Nature, vol. 499(7457), pages 214-218, July.
    • Handle: RePEc:nat:nature:v:499:y:2013:i:7457:d:10.1038_nature12213
    DOI: 10.1038/nature12213
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