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Proteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma

Author

Listed:
  • Shaoshuai Tang

    (Fudan University)

  • Yunzhi Wang

    (Fudan University)

  • Rongkui Luo

    (Fudan University)

  • Rundong Fang

    (Fudan University)

  • Yufeng Liu

    (Fudan University)

  • Hang Xiang

    (Fudan University)

  • Peng Ran

    (Fudan University)

  • Yexin Tong

    (Fudan University)

  • Mingjun Sun

    (Fudan University)

  • Subei Tan

    (Fudan University)

  • Wen Huang

    (Fudan University)

  • Jie Huang

    (Fudan University)

  • Jiacheng Lv

    (Fudan University)

  • Ning Xu

    (Fudan University)

  • Zhenmei Yao

    (Fudan University)

  • Qiao Zhang

    (Fudan University)

  • Ziyan Xu

    (Fudan University)

  • Xuetong Yue

    (Fudan University)

  • Zixiang Yu

    (Fudan University)

  • Sujie Akesu

    (Fudan University)

  • Yuqin Ding

    (Fudan University
    Shanghai Institute of Medical Imaging)

  • Chen Xu

    (Fudan University)

  • Weiqi Lu

    (Fudan University)

  • Yuhong Zhou

    (Fudan University)

  • Yingyong Hou

    (Fudan University)

  • Chen Ding

    (Fudan University)

Abstract

Soft tissue sarcoma is a broad family of mesenchymal malignancies exhibiting remarkable histological diversity. We portray the proteomic landscape of 272 soft tissue sarcomas representing 12 major subtypes. Hierarchical classification finds the similarity of proteomic features between angiosarcoma and epithelial sarcoma, and elevated expression of SHC1 in AS and ES is correlated with poor prognosis. Moreover, proteomic clustering classifies patients of soft tissue sarcoma into 3 proteomic clusters with diverse driven pathways and clinical outcomes. In the proteomic cluster featured with the high cell proliferation rate, APEX1 and NPM1 are found to promote cell proliferation and drive the progression of cancer cells. The classification based on immune signatures defines three immune subtypes with distinctive tumor microenvironments. Further analysis illustrates the potential association between immune evasion markers (PD-L1 and CD80) and tumor metastasis in soft tissue sarcoma. Overall, this analysis uncovers sarcoma-type-specific changes in proteins, providing insights about relationships of soft tissue sarcoma.

Suggested Citation

  • Shaoshuai Tang & Yunzhi Wang & Rongkui Luo & Rundong Fang & Yufeng Liu & Hang Xiang & Peng Ran & Yexin Tong & Mingjun Sun & Subei Tan & Wen Huang & Jie Huang & Jiacheng Lv & Ning Xu & Zhenmei Yao & Qi, 2024. "Proteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45306-y
    DOI: 10.1038/s41467-024-45306-y
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