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Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ

Author

Listed:
  • Zhenmei Yao

    (Fudan University)

  • Ning Xu

    (Fudan University)

  • Guoguo Shang

    (Fudan University)

  • Haixing Wang

    (Fudan University)

  • Hui Tao

    (Anhui Medical University)

  • Yunzhi Wang

    (Fudan University)

  • Zhaoyu Qin

    (Fudan University)

  • Subei Tan

    (Fudan University)

  • Jinwen Feng

    (Fudan University)

  • Jiajun Zhu

    (Fudan University)

  • Fahan Ma

    (Fudan University)

  • Sha Tian

    (Fudan University)

  • Qiao Zhang

    (Fudan University)

  • Yuanyuan Qu

    (Fudan University, Shanghai Genitourinary Cancer Institute)

  • Jun Hou

    (Fudan University)

  • Jianming Guo

    (Fudan University)

  • Jianyuan Zhao

    (Shanghai Jiao Tong University School of Medicine
    Zhengzhou University)

  • Yingyong Hou

    (Fudan University)

  • Chen Ding

    (Fudan University)

Abstract

The progression of urothelial bladder cancer (UC) is a complicated multi-step process. We perform a comprehensive multi-omics analysis of 448 samples from 190 UC patients, covering the whole spectrum of disease stages and grades. Proteogenomic integration analysis indicates the mutations of HRAS regulated mTOR signaling to form urothelial papilloma rather than papillary urothelial cancer (PUC). DNA damage is a key signaling pathway in the progression of carcinoma in situ (CIS) and related to APOBEC signature. Glucolipid metabolism increase and lower immune cell infiltration are associated with PUC compared to CIS. Proteomic analysis distinguishes the origins of invasive tumors (PUC-derived and CIS-derived), related to distinct clinical prognosis and molecular features. Additionally, loss of RBPMS, associated with CIS-derived tumors, is validated to increase the activity of AP-1 and promote metastasis. This study reveals the characteristics of two distinct branches (PUC and CIS) of UC progression and may eventually benefit clinical practice.

Suggested Citation

  • Zhenmei Yao & Ning Xu & Guoguo Shang & Haixing Wang & Hui Tao & Yunzhi Wang & Zhaoyu Qin & Subei Tan & Jinwen Feng & Jiajun Zhu & Fahan Ma & Sha Tian & Qiao Zhang & Yuanyuan Qu & Jun Hou & Jianming Gu, 2023. "Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41139-3
    DOI: 10.1038/s41467-023-41139-3
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