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The megabase-scale crossover landscape is largely independent of sequence divergence

Author

Listed:
  • Qichao Lian

    (Max Planck Institute for Plant Breeding Research)

  • Victor Solier

    (Max Planck Institute for Plant Breeding Research)

  • Birgit Walkemeier

    (Max Planck Institute for Plant Breeding Research)

  • Stéphanie Durand

    (Max Planck Institute for Plant Breeding Research)

  • Bruno Huettel

    (Max Planck Institute for Plant Breeding Research)

  • Korbinian Schneeberger

    (Max Planck Institute for Plant Breeding Research
    Faculty of Biology, LMU Munich)

  • Raphael Mercier

    (Max Planck Institute for Plant Breeding Research)

Abstract

Meiotic recombination frequency varies along chromosomes and strongly correlates with sequence divergence. However, the causal relationship between recombination landscapes and polymorphisms is unclear. Here, we characterize the genome-wide recombination landscape in the quasi-absence of polymorphisms, using Arabidopsis thaliana homozygous inbred lines in which a few hundred genetic markers were introduced through mutagenesis. We find that megabase-scale recombination landscapes in inbred lines are strikingly similar to the recombination landscapes in hybrids, with the notable exception of heterozygous large rearrangements where recombination is prevented locally. In addition, the megabase-scale recombination landscape can be largely explained by chromatin features. Our results show that polymorphisms are not a major determinant of the shape of the megabase-scale recombination landscape but rather favour alternative models in which recombination and chromatin shape sequence divergence across the genome.

Suggested Citation

  • Qichao Lian & Victor Solier & Birgit Walkemeier & Stéphanie Durand & Bruno Huettel & Korbinian Schneeberger & Raphael Mercier, 2022. "The megabase-scale crossover landscape is largely independent of sequence divergence," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31509-8
    DOI: 10.1038/s41467-022-31509-8
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    References listed on IDEAS

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    1. Cheng Luo & Xiang Li & Qinghua Zhang & Jianbing Yan, 2019. "Single gametophyte sequencing reveals that crossover events differ between sexes in maize," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    2. Carla Schmidt & Paul Fransz & Michelle Rönspies & Steven Dreissig & Jörg Fuchs & Stefan Heckmann & Andreas Houben & Holger Puchta, 2020. "Changing local recombination patterns in Arabidopsis by CRISPR/Cas mediated chromosome engineering," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    3. Penny M. A. Kianian & Minghui Wang & Kristin Simons & Farhad Ghavami & Yan He & Stefanie Dukowic-Schulze & Anitha Sundararajan & Qi Sun & Jaroslaw Pillardy & Joann Mudge & Changbin Chen & Shahryar F. , 2018. "High-resolution crossover mapping reveals similarities and differences of male and female recombination in maize," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    4. Magnus Nordborg & Tina T Hu & Yoko Ishino & Jinal Jhaveri & Christopher Toomajian & Honggang Zheng & Erica Bakker & Peter Calabrese & Jean Gladstone & Rana Goyal & Mattias Jakobsson & Sung Kim & Yuri , 2005. "The Pattern of Polymorphism in Arabidopsis thaliana," PLOS Biology, Public Library of Science, vol. 3(7), pages 1-1, May.
    5. Eugenio Mancera & Richard Bourgon & Alessandro Brozzi & Wolfgang Huber & Lars M. Steinmetz, 2008. "High-resolution mapping of meiotic crossovers and non-crossovers in yeast," Nature, Nature, vol. 454(7203), pages 479-485, July.
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    Cited by:

    1. Stéphanie Durand & Qichao Lian & Juli Jing & Marcel Ernst & Mathilde Grelon & David Zwicker & Raphael Mercier, 2022. "Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Julia Dluzewska & Wojciech Dziegielewski & Maja Szymanska-Lejman & Monika Gazecka & Ian R. Henderson & James D. Higgins & Piotr A. Ziolkowski, 2023. "MSH2 stimulates interfering and inhibits non-interfering crossovers in response to genetic polymorphism," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Maja Szymanska-Lejman & Wojciech Dziegielewski & Julia Dluzewska & Nadia Kbiri & Anna Bieluszewska & R. Scott Poethig & Piotr A. Ziolkowski, 2023. "The effect of DNA polymorphisms and natural variation on crossover hotspot activity in Arabidopsis hybrids," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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