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Maximizing meiotic crossover rates reveals the map of Crossover Potential

Author

Listed:
  • Juli Jing

    (Carl-von-Linné-Weg 10)

  • Qichao Lian

    (Carl-von-Linné-Weg 10
    South China Agricultural University)

  • Stephanie Durand

    (Carl-von-Linné-Weg 10)

  • Raphael Mercier

    (Carl-von-Linné-Weg 10)

Abstract

Sexual dysmorphism in the number and distribution of meiotic crossovers is seen across species but is poorly understood. Here, we disrupt multiple anti-crossover pathways in hermaphrodite Arabidopsis and analyze thousands of female and male progeny genomes. The greatest crossover increase is seen in zyp1 recq4 mutants, with a 12-fold rise in females and 4.5-fold in males. Additional manipulation of crossover regulators does not further increase crossovers but shifts the balance between crossover pathways, suggesting competition for a shared, limited precursor pool. While wild-type crossover patterns differ between sexes, mutant crossover landscapes converge on a unique distinct profile, which we term Crossover Potential (COP). COP can be accurately predicted using only sequence and chromatin features. We propose that COP reflects the density of eligible recombination precursors, which is determined by genomic features and is thus identical across sexes, with sexual dimorphism resulting solely from differential regulation of their maturation into crossovers.

Suggested Citation

  • Juli Jing & Qichao Lian & Stephanie Durand & Raphael Mercier, 2025. "Maximizing meiotic crossover rates reveals the map of Crossover Potential," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60663-y
    DOI: 10.1038/s41467-025-60663-y
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    References listed on IDEAS

    as
    1. Stéphanie Durand & Qichao Lian & Juli Jing & Marcel Ernst & Mathilde Grelon & David Zwicker & Raphael Mercier, 2022. "Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Eugenio Mancera & Richard Bourgon & Alessandro Brozzi & Wolfgang Huber & Lars M. Steinmetz, 2008. "High-resolution mapping of meiotic crossovers and non-crossovers in yeast," Nature, Nature, vol. 454(7203), pages 479-485, July.
    3. Qichao Lian & Victor Solier & Birgit Walkemeier & Stéphanie Durand & Bruno Huettel & Korbinian Schneeberger & Raphael Mercier, 2022. "The megabase-scale crossover landscape is largely independent of sequence divergence," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. repec:plo:pgen00:1005369 is not listed on IDEAS
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