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Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges

Author

Listed:
  • João Faro-Viana

    (CHLO, Centro Hospitalar de Lisboa Ocidental, Serviço de Patologia Clínica)

  • Marie-Louise Bergman

    (IGC, Instituto Gulbenkian de Ciência)

  • Lígia A. Gonçalves

    (IGC, Instituto Gulbenkian de Ciência)

  • Nádia Duarte

    (IGC, Instituto Gulbenkian de Ciência)

  • Teresa P. Coutinho

    (University of Lisbon)

  • Patrícia C. Borges

    (IGC, Instituto Gulbenkian de Ciência)

  • Christian Diwo

    (IGC, Instituto Gulbenkian de Ciência)

  • Rute Castro

    (IBET, Instituto de Biologia Experimental e Tecnológica)

  • Paula Matoso

    (IGC, Instituto Gulbenkian de Ciência)

  • Vanessa Malheiro

    (IGC, Instituto Gulbenkian de Ciência)

  • Ana Brennand

    (IGC, Instituto Gulbenkian de Ciência)

  • Lindsay Kosack

    (IGC, Instituto Gulbenkian de Ciência)

  • Onome Akpogheneta

    (IGC, Instituto Gulbenkian de Ciência)

  • João M. Figueira

    (CHLO, Centro Hospitalar de Lisboa Ocidental, Serviço de Patologia Clínica)

  • Conceição Cardoso

    (CHLO, Centro Hospitalar de Lisboa Ocidental, Serviço de Patologia Clínica)

  • Ana M. Casaca

    (CHLO, Centro Hospitalar de Lisboa Ocidental, Serviço de Patologia Clínica)

  • Paula M. Alves

    (IBET, Instituto de Biologia Experimental e Tecnológica
    Universidade Nova de Lisboa)

  • Telmo Nunes

    (University of Lisbon)

  • Carlos Penha-Gonçalves

    (IGC, Instituto Gulbenkian de Ciência)

  • Jocelyne Demengeot

    (IGC, Instituto Gulbenkian de Ciência)

Abstract

While mRNA vaccines are administrated worldwide in an effort to contain the COVID-19 pandemic, the heterogeneity of the humoral immune response they induce at the population scale remains unclear. Here, in a prospective, longitudinal, cohort-study, including 1245 hospital care workers and 146 nursing home residents scheduled for BNT162b2 vaccination, together covering adult ages from 19 to 99 years, we analyse seroconversion to SARS-CoV-2 spike protein and amount of spike-specific IgG, IgM and IgA before vaccination, and 3-5 weeks after each dose. We show that immunogenicity after a single vaccine dose is biased to IgG, heterogeneous and reduced with increasing age. The second vaccine dose normalizes IgG seroconversion in all age strata. These findings indicate two dose mRNA vaccines is required to reach population scale humoral immunity. The results advocate for the interval between the two doses not to be extended, and for serological monitoring of elderly and immunosuppressed vaccinees.

Suggested Citation

  • João Faro-Viana & Marie-Louise Bergman & Lígia A. Gonçalves & Nádia Duarte & Teresa P. Coutinho & Patrícia C. Borges & Christian Diwo & Rute Castro & Paula Matoso & Vanessa Malheiro & Ana Brennand & L, 2022. "Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27761-z
    DOI: 10.1038/s41467-021-27761-z
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    References listed on IDEAS

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    1. Elizabeth J. Williamson & Alex J. Walker & Krishnan Bhaskaran & Seb Bacon & Chris Bates & Caroline E. Morton & Helen J. Curtis & Amir Mehrkar & David Evans & Peter Inglesby & Jonathan Cockburn & Helen, 2020. "Factors associated with COVID-19-related death using OpenSAFELY," Nature, Nature, vol. 584(7821), pages 430-436, August.
    2. Zijun Wang & Fabian Schmidt & Yiska Weisblum & Frauke Muecksch & Christopher O. Barnes & Shlomo Finkin & Dennis Schaefer-Babajew & Melissa Cipolla & Christian Gaebler & Jenna A. Lieberman & Thiago Y. , 2021. "mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants," Nature, Nature, vol. 592(7855), pages 616-622, April.
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