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A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters

Author

Listed:
  • Phanramphoei N. Frantz

    (Université de Paris, Innovation Lab: Vaccines
    Virology and Cell Technology Laboratory)

  • Aleksandr Barinov

    (Université de Paris, Innovation Lab: Vaccines
    Viroxis)

  • Claude Ruffié

    (Université de Paris, Innovation Lab: Vaccines)

  • Chantal Combredet

    (Université de Paris, Innovation Lab: Vaccines)

  • Valérie Najburg

    (Université de Paris, Innovation Lab: Vaccines)

  • Guilherme Dias de Melo

    (Université de Paris, Lyssavirus Epidemiology and Neuropathology Unit)

  • Florence Larrous

    (Université de Paris, Lyssavirus Epidemiology and Neuropathology Unit)

  • Lauriane Kergoat

    (Université de Paris, Lyssavirus Epidemiology and Neuropathology Unit)

  • Samaporn Teeravechyan

    (Virology and Cell Technology Laboratory)

  • Anan Jongkaewwattana

    (Virology and Cell Technology Laboratory)

  • Emmanuelle Billon-Denis

    (Microbiology and infectious diseases department)

  • Jean-Nicolas Tournier

    (Microbiology and infectious diseases department)

  • Matthieu Prot

    (Université de Paris, Evolutionary Genomics of RNA viruses unit)

  • Laurine Levillayer

    (Université de Paris, Evolutionary Genomics of RNA viruses unit)

  • Laurine Conquet

    (Université de Paris, Laboratory of Mouse Genetics)

  • Xavier Montagutelli

    (Université de Paris, Laboratory of Mouse Genetics)

  • Magali Tichit

    (Université de Paris, Experimental Neuropathology unit)

  • David Hardy

    (Université de Paris, Experimental Neuropathology unit)

  • Priyanka Fernandes

    (Université de Paris, INSERM U1223, Innate Immunity unit)

  • Hélène Strick-Marchand

    (Université de Paris, INSERM U1223, Innate Immunity unit)

  • James Di Santo

    (Université de Paris, INSERM U1223, Innate Immunity unit)

  • Etienne Simon-Lorière

    (Université de Paris, Evolutionary Genomics of RNA viruses unit)

  • Hervé Bourhy

    (Université de Paris, Lyssavirus Epidemiology and Neuropathology Unit)

  • Frédéric Tangy

    (Université de Paris, Innovation Lab: Vaccines)

Abstract

Several COVID-19 vaccines have now been deployed to tackle the SARS-CoV-2 pandemic, most of them based on messenger RNA or adenovirus vectors.The duration of protection afforded by these vaccines is unknown, as well as their capacity to protect from emerging new variants. To provide sufficient coverage for the world population, additional strategies need to be tested. The live pediatric measles vaccine (MV) is an attractive approach, given its extensive safety and efficacy history, along with its established large-scale manufacturing capacity. We develop an MV-based SARS-CoV-2 vaccine expressing the prefusion-stabilized, membrane-anchored full-length S antigen, which proves to be efficient at eliciting strong Th1-dominant T-cell responses and high neutralizing antibody titers. In both mouse and golden Syrian hamster models, these responses protect the animals from intranasal infectious challenge. Additionally, the elicited antibodies efficiently neutralize in vitro the three currently circulating variants of SARS-CoV-2.

Suggested Citation

  • Phanramphoei N. Frantz & Aleksandr Barinov & Claude Ruffié & Chantal Combredet & Valérie Najburg & Guilherme Dias de Melo & Florence Larrous & Lauriane Kergoat & Samaporn Teeravechyan & Anan Jongkaeww, 2021. "A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26506-2
    DOI: 10.1038/s41467-021-26506-2
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    References listed on IDEAS

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