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SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques

Author

Listed:
  • Ramon Roozendaal

    (Janssen Vaccines & Prevention B.V.)

  • Laura Solforosi

    (Janssen Vaccines & Prevention B.V.)

  • Daniel J. Stieh

    (Janssen Vaccines & Prevention B.V.)

  • Jan Serroyen

    (Janssen Vaccines & Prevention B.V.)

  • Roel Straetemans

    (Janssen R&D)

  • Anna Dari

    (Janssen R&D)

  • Muriel Boulton

    (Janssen R&D)

  • Frank Wegmann

    (Janssen Vaccines & Prevention B.V.)

  • Sietske K. Rosendahl Huber

    (Janssen Vaccines & Prevention B.V.)

  • Joan E. M. van der Lubbe

    (Janssen Vaccines & Prevention B.V.)

  • Jenny Hendriks

    (Janssen Vaccines & Prevention B.V.)

  • Mathieu Le Gars

    (Janssen Vaccines & Prevention B.V.)

  • Liesbeth Dekking

    (Janssen Vaccines & Prevention B.V.)

  • Dominika N. Czapska-Casey

    (Janssen Vaccines & Prevention B.V.)

  • Nuria Guimera

    (Janssen Vaccines & Prevention B.V.)

  • Sarah Janssen

    (Janssen Vaccines & Prevention B.V.)

  • Sarah Tete

    (Janssen Vaccines & Prevention B.V.)

  • Abishek Chandrashekar

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Noe B. Mercado

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Jingyou Yu

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Wouter Koudstaal

    (Lucidity Biomedical Consulting)

  • Juan J. Perez-Ruixo

    (Janssen R&D)

  • Jerry Sadoff

    (Janssen Vaccines & Prevention B.V.)

  • Dan H. Barouch

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
    Ragon Institute of MGH, MIT and Harvard
    Harvard Medical School
    Massachusetts Consortium on Pathogen Readiness)

  • Hanneke Schuitemaker

    (Janssen Vaccines & Prevention B.V.)

  • Roland Zahn

    (Janssen Vaccines & Prevention B.V.)

Abstract

Several COVID-19 vaccines have recently gained authorization for emergency use. Limited knowledge on duration of immunity and efficacy of these vaccines is currently available. Data on other coronaviruses after natural infection suggest that immunity to SARS-CoV-2 might be short-lived, and preliminary evidence indicates waning antibody titers following SARS-CoV-2 infection. In this work, we model the relationship between immunogenicity and protective efficacy of a series of Ad26 vectors encoding stabilized variants of the SARS-CoV-2 Spike protein in rhesus macaques and validate the analyses by challenging macaques 6 months after immunization with the Ad26.COV2.S vaccine candidate that has been selected for clinical development. We show that Ad26.COV2.S confers durable protection against replication of SARS-CoV-2 in the lungs that is predicted by the levels of Spike-binding and neutralizing antibodies, indicating that Ad26.COV2.S could confer durable protection in humans and immunological correlates of protection may enable the prediction of durability of protection.

Suggested Citation

  • Ramon Roozendaal & Laura Solforosi & Daniel J. Stieh & Jan Serroyen & Roel Straetemans & Anna Dari & Muriel Boulton & Frank Wegmann & Sietske K. Rosendahl Huber & Joan E. M. van der Lubbe & Jenny Hend, 2021. "SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26117-x
    DOI: 10.1038/s41467-021-26117-x
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    References listed on IDEAS

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