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Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms

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  • Gilvania Barreto Feitosa Coutinho

    (Center for Studies on the Worker’s Health and Human Ecology, Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, 1480 Leopoldo Bulhões St., Rio de Janeiro 21041-210, RJ, Brazil)

  • Maria de Fátima Ramos Moreira

    (Center for Studies on the Worker’s Health and Human Ecology, Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, 1480 Leopoldo Bulhões St., Rio de Janeiro 21041-210, RJ, Brazil)

  • Frida Marina Fischer

    (Department of Environmental Health, School of Public Health, University of São Paulo, São Paulo 01246-904, SP, Brazil)

  • Maria Carolina Reis dos Santos

    (Center for Studies on the Worker’s Health and Human Ecology, Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, 1480 Leopoldo Bulhões St., Rio de Janeiro 21041-210, RJ, Brazil)

  • Lucas Ferreira Feitosa

    (Center for Studies on the Worker’s Health and Human Ecology, Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, 1480 Leopoldo Bulhões St., Rio de Janeiro 21041-210, RJ, Brazil)

  • Sayonara Vieira de Azevedo

    (Center for Studies on the Worker’s Health and Human Ecology, Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, 1480 Leopoldo Bulhões St., Rio de Janeiro 21041-210, RJ, Brazil)

  • Renato Marçullo Borges

    (Center for Studies on the Worker’s Health and Human Ecology, Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, 1480 Leopoldo Bulhões St., Rio de Janeiro 21041-210, RJ, Brazil)

  • Michelle Nascimento-Sales

    (Center for Natural and Human Sciences (CCNH), ABC Federal University (UFABC), Santo André 09210-580, SP, Brazil
    Centro de Ciências Biológicas e de Saúde (CBS), Universidade Cruzeiro do Sul (Unicsul), São Paulo 01506-000, SP, Brazil)

  • Marcelo Augusto Christoffolete

    (Center for Natural and Human Sciences (CCNH), ABC Federal University (UFABC), Santo André 09210-580, SP, Brazil)

  • Marden Samir Santa-Marinha

    (Center for Studies on the Worker’s Health and Human Ecology, Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, 1480 Leopoldo Bulhões St., Rio de Janeiro 21041-210, RJ, Brazil)

  • Daniel Valente

    (Center for Studies on the Worker’s Health and Human Ecology, Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, 1480 Leopoldo Bulhões St., Rio de Janeiro 21041-210, RJ, Brazil)

  • Liliane Reis Teixeira

    (Center for Studies on the Worker’s Health and Human Ecology, Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, 1480 Leopoldo Bulhões St., Rio de Janeiro 21041-210, RJ, Brazil)

Abstract

Objective: To evaluate the association between environmental exposure to the following chemical substances: cadmium (Cd), lead (Pb), nickel (Ni), manganese (Mn), benzene (BZN), and toluene (TLN), and Period Circadian Regulator 3 ( PER3 ) gene variable number of tandem repeats (VNTR) polymorphisms, according to chronotype in a population living in a steel residue-contaminated area. Methods: This assessment comprises a study conducted from 2017 to 2019 with 159 participants who completed health, work, and Pittsburgh sleep scale questionnaires. Cd, Pb, Ni, Mn, BZN, and TLN concentrations in blood and urine were determined by Graphite Furnace Atomic Absorption Spectrometry (GFAAS) and Headspace Gas Chromatography (GC), and genotyping was carried out using Polymerase Chain Reaction (PCR). Results: A total of 47% of the participants were afternoon chronotype, 42% were indifferent, and 11% were morning chronotype. Insomnia and excessive sleepiness were associated with the indifferent chronotype, while higher urinary manganese levels were associated with the morning chronotype (Kruskal–Wallis chi-square = 9.16; p < 0.01). In turn, the evening chronotype was associated with poorer sleep quality, higher lead levels in blood, and BZN and TLN levels in urine (χ 2 = 11.20; p < 0.01) in non-occupationally exposed individuals (χ 2 = 6.98; p < 0.01) as well as the highest BZN (χ 2 = 9.66; p < 0.01) and TLN (χ 2 = 5.71; p < 0.01) levels detected in residents from the influence zone 2 (far from the slag). Conclusion: Mn, Pb, benzene, and toluene contaminants may have influenced the different chronotypes found in the steel residue-exposed population.

Suggested Citation

  • Gilvania Barreto Feitosa Coutinho & Maria de Fátima Ramos Moreira & Frida Marina Fischer & Maria Carolina Reis dos Santos & Lucas Ferreira Feitosa & Sayonara Vieira de Azevedo & Renato Marçullo Borges, 2023. "Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation and PER3 Gene Polymorphisms," IJERPH, MDPI, vol. 20(6), pages 1-21, March.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:6:p:4760-:d:1090913
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    1. Uchenna Okereafor & Mamookho Makhatha & Lukhanyo Mekuto & Nkemdinma Uche-Okereafor & Tendani Sebola & Vuyo Mavumengwana, 2020. "Toxic Metal Implications on Agricultural Soils, Plants, Animals, Aquatic life and Human Health," IJERPH, MDPI, vol. 17(7), pages 1-24, March.
    2. Xuexia Chen & Shuai Zhang & Lijin Yi & Zhengwei Liu & Xiangyu Ye & Bo Yu & Shuai Shi & Xiaoxia Lu, 2022. "Evaluation of Biodegradation of BTEX in the Subsurface of a Petrochemical Site near the Yangtze River, China," IJERPH, MDPI, vol. 19(24), pages 1-12, December.
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