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Survival Disparities in US Black Compared to White Women with Hormone Receptor Positive-HER2 Negative Breast Cancer

Author

Listed:
  • Leann A. Lovejoy

    (Chan Soon-Shiong Institute of Molecular Medicine at Windber, Windber, PA 15963, USA)

  • Craig D. Shriver

    (Murtha Cancer Center/Research Program, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD 20889, USA
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA)

  • Svasti Haricharan

    (Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA)

  • Rachel E. Ellsworth

    (Murtha Cancer Center/Research Program, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD 20889, USA
    Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA)

Abstract

Black women in the US have significantly higher breast cancer mortality than White women. Within biomarker-defined tumor subtypes, disparate outcomes seem to be limited to women with hormone receptor positive and HER2 negative (HR+/HER2−) breast cancer, a subtype usually associated with favorable prognosis. In this review, we present data from an array of studies that demonstrate significantly higher mortality in Black compared to White women with HR+/HER2-breast cancer and contrast these data to studies from integrated healthcare systems that failed to find survival differences. Then, we describe factors, both biological and non-biological, that may contribute to disparate survival in Black women.

Suggested Citation

  • Leann A. Lovejoy & Craig D. Shriver & Svasti Haricharan & Rachel E. Ellsworth, 2023. "Survival Disparities in US Black Compared to White Women with Hormone Receptor Positive-HER2 Negative Breast Cancer," IJERPH, MDPI, vol. 20(4), pages 1-15, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:2903-:d:1060509
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    References listed on IDEAS

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    1. Charles M. Perou & Therese Sørlie & Michael B. Eisen & Matt van de Rijn & Stefanie S. Jeffrey & Christian A. Rees & Jonathan R. Pollack & Douglas T. Ross & Hilde Johnsen & Lars A. Akslen & Øystein Flu, 2000. "Molecular portraits of human breast tumours," Nature, Nature, vol. 406(6797), pages 747-752, August.
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