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The Gaseous Ozone Therapy as a Promising Antiseptic Adjuvant of Periodontal Treatment: A Randomized Controlled Clinical Trial

Author

Listed:
  • Biagio Rapone

    (Interdisciplinary Department of Medicine, “Aldo Moro” University of Bari, 70121 Bari, Italy)

  • Elisabetta Ferrara

    (Complex Operative Unit of Odontostomatology, Hospital S.S. Annunziata, 66100 Chieti, Italy)

  • Luigi Santacroce

    (Complex Operative Unit of Odontostomatology, Hospital S.S. Annunziata, 66100 Chieti, Italy)

  • Skender Topi

    (Department of Clinical Disciplines, School of Technical Medical Sciences, University A. Xhuvani, 3001 Elbasan, Albania)

  • Antonio Gnoni

    (Department of Basic Medical Sciences, Neurosciences and Sense Organs, “Aldo Moro” University of Bari, 70121 Bari, Italy)

  • Gianna Dipalma

    (Interdisciplinary Department of Medicine, “Aldo Moro” University of Bari, 70121 Bari, Italy)

  • Antonio Mancini

    (Interdisciplinary Department of Medicine, “Aldo Moro” University of Bari, 70121 Bari, Italy)

  • Marina Di Domenico

    (Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy)

  • Gianluca Martino Tartaglia

    (UOC Maxillo-Facial Surgery and Dentistry, Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, University of Milan, 20100 Milan, Italy)

  • Antonio Scarano

    (Department of Oral Science, Nano and Biotechnology and CeSi-Met University of Chieti-Pescara, 66100 Chieti, Italy
    These authors contributed equally to this work.)

  • Francesco Inchingolo

    (Interdisciplinary Department of Medicine, “Aldo Moro” University of Bari, 70121 Bari, Italy
    These authors contributed equally to this work.)

Abstract

Background: the establishment of periodontitis is regulated by the primary etiological factor and several individual conditions including the immune response mechanism of the host and individual genetic factors. It results when the oral homeostasis is interrupted, and biological reactions favor the development and progression of periodontal tissues damage. Different strategies have been explored for reinforcing the therapeutic effect of non-surgical periodontal treatment of periodontal tissue damage. Gaseous ozone therapy has been recognized as a promising antiseptic adjuvant, because of its immunostimulating, antimicrobial, antihypoxic, and biosynthetic effects. Then, we hypothesized that the adjunct of gaseous ozone therapy to standard periodontal treatment may be leveraged to promote the tissue healing response. Methods: to test this hypothesis, we conducted a prospective randomized study comparing non-surgical periodontal treatment plus gaseous ozone therapy to standard therapy. A total of 90 healthy individuals with moderate or severe generalized periodontitis were involved in the study. The trial was conducted from September 2019 to October 2020. Forty-five patients were randomized to receive scaling and root-planning (SRP) used as conventional non-surgical periodontal therapy plus gaseous ozone therapy (GROUP A); forty-five were allocated to standard treatment (GROUP B). The endpoint was defined as the periodontal response rate after the application of the ozone therapy at 3 months and 6 months, defined as no longer meeting the criteria for active periodontitis. Statistical analysis was performed employing SPSS v.18 Chicago: SPSS Inc. Results: periodontal parameters differed significantly between patients treated with the two distinct procedures at 3 months ( p ≤ 0.005); a statistically significant difference between groups was observed from baseline in the CAL ( p ≤ 0.0001), PPD ( p ≤ 0.0001) and BOP ( p ≤ 0.0001) scores. Conclusions: The present study suggests that SRP combined with ozone therapy in the treatment of periodontitis revealed an improved outcome than SRP alone.

Suggested Citation

  • Biagio Rapone & Elisabetta Ferrara & Luigi Santacroce & Skender Topi & Antonio Gnoni & Gianna Dipalma & Antonio Mancini & Marina Di Domenico & Gianluca Martino Tartaglia & Antonio Scarano & Francesco , 2022. "The Gaseous Ozone Therapy as a Promising Antiseptic Adjuvant of Periodontal Treatment: A Randomized Controlled Clinical Trial," IJERPH, MDPI, vol. 19(2), pages 1-14, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:2:p:985-:d:725882
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    References listed on IDEAS

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    1. Nicola Montemurro & Paolo Perrini & Biagio Rapone, 2020. "Clinical Risk and Overall Survival in Patients with Diabetes Mellitus, Hyperglycemia and Glioblastoma Multiforme. A Review of the Current Literature," IJERPH, MDPI, vol. 17(22), pages 1-18, November.
    2. Field, Andy Peter Professor & Wilcox, Rand R., 2017. "Robust statistical methods: a primer for clinical psychology and experimental psychopathology researchers," OSF Preprints v3nz4, Center for Open Science.
    3. Camilla Preda & Andrea Butera & Silvia Pelle & Eleonora Pautasso & Alessandro Chiesa & Francesca Esposito & Giacomo Oldoini & Andrea Scribante & Anna Maria Genovesi & Saverio Cosola, 2021. "The Efficacy of Powered Oscillating Heads vs. Powered Sonic Action Heads Toothbrushes to Maintain Periodontal and Peri-Implant Health: A Narrative Review," IJERPH, MDPI, vol. 18(4), pages 1-17, February.
    4. Antonio Scarano & Francesco Inchingolo & Biagio Rapone & Felice Festa & Sergio Rexhep Tari & Felice Lorusso, 2021. "Protective Face Masks: Effect on the Oxygenation and Heart Rate Status of Oral Surgeons during Surgery," IJERPH, MDPI, vol. 18(5), pages 1-10, February.
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    1. Kacper Nijakowski & Dawid Gruszczyński & Julia Kolasińska & Dariusz Kopała & Anna Surdacka, 2022. "Periodontal Disease in Patients with Psoriasis: A Systematic Review," IJERPH, MDPI, vol. 19(18), pages 1-15, September.

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