IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i20p13063-d939131.html
   My bibliography  Save this article

DEPs Induce Local Ige Class Switching Independent of Their Ability to Stimulate iBALT de Novo Formation

Author

Listed:
  • Dmitrii Borisovich Chudakov

    (Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya Str., Moscow 117997, Russia)

  • Mariya Vladimirovna Konovalova

    (Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya Str., Moscow 117997, Russia)

  • Elena Igorevna Kashirina

    (Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya Str., Moscow 117997, Russia)

  • Olga Dmitrievna Kotsareva

    (Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya Str., Moscow 117997, Russia)

  • Marina Alexandrovna Shevchenko

    (Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya Str., Moscow 117997, Russia)

  • Daria Sergeevna Tsaregorodtseva

    (Faculty of Medical Biology, Sechenov First Moscow State Medical University, 2 Bolshaya Pirogovskaya Str., Moscow 1194535, Russia)

  • Gulnar Vaisovna Fattakhova

    (Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya Str., Moscow 117997, Russia)

Abstract

Background: Diesel exhaust particles (DEPs) are leading to a general increase in atopic diseases worldwide. However, it is still unknown whether DEPs induce systemic B-cell IgE class switching in secondary lymphoid organs or locally in the lungs in inducible bronchus-associated lymphoid tissue (iBALT). The aim of this work was to identify the exact site of DEP-mediated B-cell IgE class switching and pro-allergic antibody production. Methods: We immunized BALB/c mice with different OVA doses (0.3 and 30 µg) intranasally in the presence and absence of two types of DEPs, SRM1650B and SRM2786. We used low (30 µg) and high (150 µg) DEP doses. Results: Only a high DEP dose induced IgE production, regardless of the particle type. Local IgE class switching was stimulated upon treatment with both types of particles with both low and high OVA doses. Despite the similar ability of the two standard DEPs to stimulate IgE production, their ability to induce iBALT formation and growth was markedly different upon co-administration with low OVA doses. Conclusions: DEP-induced local IgE class switching takes place in preexisting iBALTs independent of de novo iBALT formation, at least in the case of SRM1650B co-administered with low OVA doses.

Suggested Citation

  • Dmitrii Borisovich Chudakov & Mariya Vladimirovna Konovalova & Elena Igorevna Kashirina & Olga Dmitrievna Kotsareva & Marina Alexandrovna Shevchenko & Daria Sergeevna Tsaregorodtseva & Gulnar Vaisovna, 2022. "DEPs Induce Local Ige Class Switching Independent of Their Ability to Stimulate iBALT de Novo Formation," IJERPH, MDPI, vol. 19(20), pages 1-24, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:20:p:13063-:d:939131
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/20/13063/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/20/13063/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Pier Mannuccio Mannucci & Massimo Franchini, 2017. "Health Effects of Ambient Air Pollution in Developing Countries," IJERPH, MDPI, vol. 14(9), pages 1-8, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xiang Wu & Lindong Liu & Xiaowei Luo & Jianwu Chen & Jingwen Dai, 2018. "Study on Flow Field Characteristics of the 90° Rectangular Elbow in the Exhaust Hood of a Uniform Push–Pull Ventilation Device," IJERPH, MDPI, vol. 15(12), pages 1-12, December.
    2. Myung-Jae Hwang & Jong-Hun Kim & Hae-Kwan Cheong, 2020. "Short-Term Impacts of Ambient Air Pollution on Health-Related Quality of Life: A Korea Health Panel Survey Study," IJERPH, MDPI, vol. 17(23), pages 1-11, December.
    3. Jagriti Saini & Maitreyee Dutta & Gonçalo Marques, 2020. "Indoor Air Quality Monitoring Systems Based on Internet of Things: A Systematic Review," IJERPH, MDPI, vol. 17(14), pages 1-22, July.
    4. Ahmad Alkhatib & Lawrence Achilles Nnyanzi & Brian Mujuni & Geofrey Amanya & Charles Ibingira, 2021. "Preventing Multimorbidity with Lifestyle Interventions in Sub-Saharan Africa: A New Challenge for Public Health in Low and Middle-Income Countries," IJERPH, MDPI, vol. 18(23), pages 1-14, November.
    5. Wei Chen & Jian Chen & Guopeng Yin, 2022. "Exploring side effects of ridesharing services in urban China: role of pollution–averting behavior," Electronic Commerce Research, Springer, vol. 22(4), pages 1007-1034, December.
    6. Mattia Acito & Cristina Fatigoni & Milena Villarini & Massimo Moretti, 2022. "Cytogenetic Effects in Children Exposed to Air Pollutants: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(11), pages 1-17, May.
    7. Daniela Varrica & Maria Grazia Alaimo, 2022. "Determination of Water-Soluble Trace Elements in the PM 10 and PM 2.5 of Palermo Town (Italy)," IJERPH, MDPI, vol. 20(1), pages 1-13, December.
    8. Sylvester Dodzi Nyadanu & Gizachew Assefa Tessema & Ben Mullins & Bernard Kumi-Boateng & Michelle Lee Bell & Gavin Pereira, 2020. "Ambient Air Pollution, Extreme Temperatures and Birth Outcomes: A Protocol for an Umbrella Review, Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(22), pages 1-18, November.
    9. Dalia M. Muñoz-Pizza & Mariana Villada-Canela & M. A. Reyna & José Luis Texcalac-Sangrador & Jesús Serrano-Lomelin & Álvaro Osornio-Vargas, 2020. "Assessing the Influence of Socioeconomic Status and Air Pollution Levels on the Public Perception of Local Air Quality in a Mexico-US Border City," IJERPH, MDPI, vol. 17(13), pages 1-22, June.
    10. Balasooriya, Namal N. & Bandara, Jayatilleke S. & Rohde, Nicholas, 2022. "Air pollution and health outcomes: Evidence from Black Saturday Bushfires in Australia," Social Science & Medicine, Elsevier, vol. 306(C).
    11. Jelonia T. Rumph & Victoria R. Stephens & Joanie L. Martin & LaKendria K. Brown & Portia L. Thomas & Ayorinde Cooley & Kevin G. Osteen & Kaylon L. Bruner-Tran, 2022. "Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women’s Health," IJERPH, MDPI, vol. 19(3), pages 1-22, January.
    12. Qin Song & Yu-Jun Zheng & Jun Yang, 2019. "Effects of Food Contamination on Gastrointestinal Morbidity: Comparison of Different Machine-Learning Methods," IJERPH, MDPI, vol. 16(5), pages 1-12, March.
    13. Karl Kilbo Edlund & Felicia Killman & Peter Molnár & Johan Boman & Leo Stockfelt & Janine Wichmann, 2021. "Health Risk Assessment of PM 2.5 and PM 2.5 -Bound Trace Elements in Thohoyandou, South Africa," IJERPH, MDPI, vol. 18(3), pages 1-11, February.
    14. Shankar Subramaniam & Naveenkumar Raju & Abbas Ganesan & Nithyaprakash Rajavel & Maheswari Chenniappan & Chander Prakash & Alokesh Pramanik & Animesh Kumar Basak & Saurav Dixit, 2022. "Artificial Intelligence Technologies for Forecasting Air Pollution and Human Health: A Narrative Review," Sustainability, MDPI, vol. 14(16), pages 1-36, August.
    15. Muhammad Zafar Yaqub & Rana Muhammad Shahid Yaqub & Tahira Riaz & Hani Abdulrehman Alamri, 2023. "Prolificacy of Green Consumption Orientation and Environmental Knowledge to Slash Plastic Bag Consumption: The Moderating Role of Consumer Attitudes and the Demarketing Efforts," Sustainability, MDPI, vol. 15(13), pages 1-15, June.
    16. Barouch Giechaskiel & Pierre Bonnel & Adolfo Perujo & Panagiota Dilara, 2019. "Solid Particle Number (SPN) Portable Emissions Measurement Systems (PEMS) in the European Legislation: A Review," IJERPH, MDPI, vol. 16(23), pages 1-23, November.
    17. Sajith Priyankara & Mahesh Senarathna & Rohan Jayaratne & Lidia Morawska & Sachith Abeysundara & Rohan Weerasooriya & Luke D. Knibbs & Shyamali C. Dharmage & Duminda Yasaratne & Gayan Bowatte, 2021. "Ambient PM 2.5 and PM 10 Exposure and Respiratory Disease Hospitalization in Kandy, Sri Lanka," IJERPH, MDPI, vol. 18(18), pages 1-13, September.
    18. Mingxiao Li & Song Gao & Feng Lu & Huan Tong & Hengcai Zhang, 2019. "Dynamic Estimation of Individual Exposure Levels to Air Pollution Using Trajectories Reconstructed from Mobile Phone Data," IJERPH, MDPI, vol. 16(22), pages 1-20, November.
    19. Chaiwat Bumroongkit & Chalerm Liwsrisakun & Athavudh Deesomchok & Chaicharn Pothirat & Theerakorn Theerakittikul & Atikun Limsukon & Konlawij Trongtrakul & Pattraporn Tajarernmuang & Nutchanok Niyatiw, 2022. "Correlation of Air Pollution and Prevalence of Acute Pulmonary Embolism in Northern Thailand," IJERPH, MDPI, vol. 19(19), pages 1-11, October.
    20. Mona Elbarbary & Trenton Honda & Geoffrey Morgan & Yuming Guo & Yanfei Guo & Paul Kowal & Joel Negin, 2020. "Ambient Air Pollution Exposure Association with Anaemia Prevalence and Haemoglobin Levels in Chinese Older Adults," IJERPH, MDPI, vol. 17(9), pages 1-15, May.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:20:p:13063-:d:939131. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.