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Insulin Resistance Is Associated with Multiple Chemical Sensitivity in a Danish Population-Based Study—DanFunD

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  • Anne A. Bjerregaard

    (Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Nordre Fasanvej 57, Hovedvejen, Entrance 5, 2000 Frederiksberg, Denmark
    Department of Epidemiology Research, Statens Serum Institut, Artillerivej 3, 2300 Copenhagen, Denmark)

  • Marie W. Petersen

    (Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Universitetsbyen 22–23, 8000 Aarhus C, Denmark)

  • Lise Kirstine Gormsen

    (Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Universitetsbyen 22–23, 8000 Aarhus C, Denmark)

  • Sine Skovbjerg

    (The Danish Center for Mindfulness, Department of Clinical Medicine, Aarhus University, Hack Kampmanns Plads, 8000 Aarhus C, Denmark)

  • Niklas R. Jørgensen

    (Department of Clinical Biochemistry, Rigshospitalet, Valdemar Hansens Vej 13, 2600 Glostrup, Denmark
    Institute of Clinical Medicine, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark)

  • Allan Linneberg

    (Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Nordre Fasanvej 57, Hovedvejen, Entrance 5, 2000 Frederiksberg, Denmark
    Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark)

  • José G. Cedeño-Laurent

    (Department of Exposure Epidemiology and Risk Program, Harvard T.H. Chan School of Public Health, 1350 Massachusetts Ave, Cambridge, MA 02138, USA)

  • Torben Jørgensen

    (Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Nordre Fasanvej 57, Hovedvejen, Entrance 5, 2000 Frederiksberg, Denmark
    Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark)

  • Thomas M. Dantoft

    (Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Nordre Fasanvej 57, Hovedvejen, Entrance 5, 2000 Frederiksberg, Denmark)

Abstract

Multiple chemical sensitivity (MCS) is a multisystem syndrome, and limited knowledge of its pathophysiology exists. Based on the population-based Danish cohort DanFunD , this study investigated metabolic health in people with MCS compared to individuals who did not have MCS. From 9656 cohort participants aged 18–76 years old, 1.95% were categorized as MCS individuals with comorbid functional somatic disorders (MCS + FSD , n = 188), and 1.13% were categorized as MCS without functional somatic disorders (MCS ÷ FSD , n = 109). MCS was characterized based on three criteria: the experience of symptoms upon exposure to common odors and airborne chemicals, symptoms related the central nervous systems and others organ symptoms, and significant impact on every day, social, and occupational life. The remaining study population without MCS or any other functional somatic disorders were regarded as controls. We used adjusted multiple linear regression with link-function to evaluate the associations between lipid and glucose metabolism markers and MCS. We also tested the odds ratio of metabolic syndrome in MCS. Results did not point to statistically significant associations between lipid biomarkers or metabolic syndrome and both MCS groups compared to the controls. We found that MCS individuals may be more insulin resistant and that MCS ÷ FSD may have an impaired glucose metabolism when compared to controls.

Suggested Citation

  • Anne A. Bjerregaard & Marie W. Petersen & Lise Kirstine Gormsen & Sine Skovbjerg & Niklas R. Jørgensen & Allan Linneberg & José G. Cedeño-Laurent & Torben Jørgensen & Thomas M. Dantoft, 2021. "Insulin Resistance Is Associated with Multiple Chemical Sensitivity in a Danish Population-Based Study—DanFunD," IJERPH, MDPI, vol. 18(23), pages 1-13, November.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:23:p:12654-:d:692331
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    References listed on IDEAS

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    1. Giovanni Damiani & Marco Alessandrini & Daniela Caccamo & Andrea Cormano & Gianpaolo Guzzi & Andrea Mazzatenta & Alessandro Micarelli & Alberto Migliore & Alba Piroli & Margherita Bianca & Ottaviano T, 2021. "Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)," IJERPH, MDPI, vol. 18(21), pages 1-19, October.
    2. Caress, S.M. & Steinemann, A.C., 2004. "Prevalence of Multiple Chemical Sensitivities: A Population-Based Study in the Southeastern United States," American Journal of Public Health, American Public Health Association, vol. 94(5), pages 746-747.
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