IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i20p10849-d657287.html
   My bibliography  Save this article

Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Author

Listed:
  • Neeranuch Suwannarin

    (Ph.D. Degree Program in Environmental Science, Environmental Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
    Environmental and Occupational Health Sciences and Non-Communicable Diseases Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
    Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-8506, Japan)

  • Tippawan Prapamontol

    (Environmental and Occupational Health Sciences and Non-Communicable Diseases Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Tomohiko Isobe

    (Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-8506, Japan)

  • Yukiko Nishihama

    (Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-8506, Japan)

  • Ampica Mangklabruks

    (Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Tawiwan Pantasri

    (Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Somporn Chantara

    (Environmental Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Warangkana Naksen

    (Faculty of Public Health, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Shoji F. Nakayama

    (Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-8506, Japan)

Abstract

Exposure to insecticides may result in various health problems. This study investigated the association between haematological parameters and exposure to a mixture of organophosphate (OP) and neonicotinoid (NEO) insecticides among male farmworkers in Fang district, Chiang Mai province, northern Thailand. Concentrations of urinary dialkylphosphates, non-specific metabolites of OPs, and NEOs and their metabolites and haematological parameters were measured in 143 male farmworkers. The Bayesian kernel machine regression model was employed to evaluate the associations. Exposure to a mixture of insecticides was significantly associated with the mean corpuscular haemoglobin concentration (MCHC) when the concentrations of all the compounds and their metabolites were at the 60th percentile or higher compared with the 50th percentile. Furthermore, exposure to clothianidin (CLO) showed a decreasing association with MCHC when all the other insecticides were at their mean concentrations. CLO was the most likely compound to reduce MCHC, and this was confirmed by sensitivity analysis. These findings suggest that exposure to NEO insecticides, especially CLO, affects the haematological status relating to haemoglobin parameters.

Suggested Citation

  • Neeranuch Suwannarin & Tippawan Prapamontol & Tomohiko Isobe & Yukiko Nishihama & Ampica Mangklabruks & Tawiwan Pantasri & Somporn Chantara & Warangkana Naksen & Shoji F. Nakayama, 2021. "Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand," IJERPH, MDPI, vol. 18(20), pages 1-14, October.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:20:p:10849-:d:657287
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/20/10849/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/20/10849/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Alyson N. Lorenz & Tippawan Prapamontol & Warangkana Narksen & Niphan Srinual & Dana B. Barr & Anne M. Riederer, 2012. "Pilot Study of Pesticide Knowledge, Attitudes, and Practices among Pregnant Women in Northern Thailand," IJERPH, MDPI, vol. 9(9), pages 1-19, September.
    2. Neeranuch Suwannarin & Tippawan Prapamontol & Tomohiko Isobe & Yukiko Nishihama & Shoji F. Nakayama, 2020. "Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study," IJERPH, MDPI, vol. 17(21), pages 1-14, October.
    3. Soraya Aroonvilairat & Wannapa Kespichayawattana & Thiwaree Sornprachum & Papada Chaisuriya & Taweeratana Siwadune & Kavi Ratanabanangkoon, 2015. "Effect of Pesticide Exposure on Immunological, Hematological and Biochemical Parameters in Thai Orchid Farmers— A Cross-Sectional Study," IJERPH, MDPI, vol. 12(6), pages 1-16, May.
    4. Neeranuch Suwannarin & Tippawan Prapamontol & Tomohiko Isobe & Yukiko Nishihama & Yuki Hashimoto & Ampica Mangklabruks & Tawiwan Pantasri & Somporn Chantara & Warangkana Naksen & Shoji F. Nakayama, 2021. "Exposure to Organophosphate and Neonicotinoid Insecticides and Its Association with Steroid Hormones among Male Reproductive-Age Farmworkers in Northern Thailand," IJERPH, MDPI, vol. 18(11), pages 1-16, May.
    5. Pornpimol Kongtip & Benyachalee Techasaensiri & Noppanun Nankongnab & Jane Adams & Akkarat Phamonphon & Anu Surach & Supha Sangprasert & Aree Thongsuksai & Prayoon Srikumpol & Susan Woskie, 2017. "The Impact of Prenatal Organophosphate Pesticide Exposures on Thai Infant Neurodevelopment," IJERPH, MDPI, vol. 14(6), pages 1-12, May.
    6. Christina Gillezeau & Naomi Alpert & Priyanka Joshi & Emanuela Taioli, 2019. "Urinary Dialkylphosphate Metabolite Levels in US Adults—National Health and Nutrition Examination Survey 1999–2008," IJERPH, MDPI, vol. 16(23), pages 1-10, November.
    7. Matome M. Sekhotha & Kotsedi D. Monyeki & Masezi E. Sibuyi, 2016. "Exposure to Agrochemicals and Cardiovascular Disease: A Review," IJERPH, MDPI, vol. 13(2), pages 1-12, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Neeranuch Suwannarin & Tippawan Prapamontol & Tomohiko Isobe & Yukiko Nishihama & Shoji F. Nakayama, 2020. "Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study," IJERPH, MDPI, vol. 17(21), pages 1-14, October.
    2. Neeranuch Suwannarin & Tippawan Prapamontol & Tomohiko Isobe & Yukiko Nishihama & Yuki Hashimoto & Ampica Mangklabruks & Tawiwan Pantasri & Somporn Chantara & Warangkana Naksen & Shoji F. Nakayama, 2021. "Exposure to Organophosphate and Neonicotinoid Insecticides and Its Association with Steroid Hormones among Male Reproductive-Age Farmworkers in Northern Thailand," IJERPH, MDPI, vol. 18(11), pages 1-16, May.
    3. Alberto Arnedo-Pena & Joan Puig-Barberà & Juan Bellido-Blasco & MªAngeles Romeu-Garcia & Mª Rosario Pac-Sa & Francisco Guillen-Grima, 2020. "Production of Vegetables and Artichokes Is Associated with Lower Cardiovascular Mortality: An Ecological Study," IJERPH, MDPI, vol. 17(18), pages 1-16, September.
    4. Judit Biosca-Brull & Cristian Pérez-Fernández & Santiago Mora & Beatriz Carrillo & Helena Pinos & Nelida Maria Conejo & Paloma Collado & Jorge L. Arias & Fernando Martín-Sánchez & Fernando Sánchez-San, 2021. "Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models," IJERPH, MDPI, vol. 18(10), pages 1-30, May.
    5. Xile Deng & Yong Zhou & Wenna Zheng & Lianyang Bai & Xiaomao Zhou, 2018. "Dissipation Dynamic and Final Residues of Oxadiargyl in Paddy Fields Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry Coupled with Modified QuEChERS Method," IJERPH, MDPI, vol. 15(8), pages 1-10, August.
    6. Pajaree Konthonbut & Pornpimol Kongtip & Noppanun Nankongnab & Mathuros Tipayamongkholgul & Witaya Yoosook & Susan Woskie, 2018. "Paraquat Exposure of Pregnant Women and Neonates in Agricultural Areas in Thailand," IJERPH, MDPI, vol. 15(6), pages 1-14, June.
    7. Yukiko Nishihama & Shoji F. Nakayama & Tomohiko Isobe & Chau-Ren Jung & Miyuki Iwai-Shimada & Yayoi Kobayashi & Takehiro Michikawa & Makiko Sekiyama & Yu Taniguchi & Shin Yamazaki & on behalf of the J, 2021. "Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)," IJERPH, MDPI, vol. 18(11), pages 1-13, May.
    8. Hans-Peter Hutter & Hanns Moshammer, 2018. "Pesticides Are an Occupational and Public Health Issue," IJERPH, MDPI, vol. 15(8), pages 1-3, August.
    9. Maud Miguet & Gull Rukh & Olga E. Titova & Helgi B. Schiöth, 2020. "Important Difference between Occupational Hazard Exposure among Shift Workers and Other Workers; Comparing Workplace before and after 1980," IJERPH, MDPI, vol. 17(20), pages 1-12, October.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:20:p:10849-:d:657287. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.