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Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

Author

Listed:
  • Yukiko Nishihama

    (Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan)

  • Shoji F. Nakayama

    (Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan)

  • Tomohiko Isobe

    (Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan)

  • Chau-Ren Jung

    (Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan
    Department of Public Health, College of Public Health, China Medical University, Taichung City 406040, Taiwan)

  • Miyuki Iwai-Shimada

    (Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan)

  • Yayoi Kobayashi

    (Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan)

  • Takehiro Michikawa

    (Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan
    Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo 143-8540, Japan)

  • Makiko Sekiyama

    (Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan)

  • Yu Taniguchi

    (Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan)

  • Shin Yamazaki

    (Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan)

  • on behalf of the Japan Environment and Children’s Study Group

    (Membership of the Japan Environment and Children’s Study Group is provided in the Acknowledgements.)

Abstract

Organophosphate pesticides (OPPs) exhibit neurodevelopmental toxicity. To evaluate the effect of prenatal exposure to OPPs in the Japan Environment and Children’s Study, a nationally representative birth cohort study, 4575 maternal urine samples were analysed for six OPP metabolites, i.e., dialkylphosphates (DAPs). This study aimed to investigate predictors of urinary DAPs using machine learning approaches and to assess the cumulative risk based on relative potency factors among Japanese pregnant women. The median creatinine-normalised urinary concentrations (interquartile ranges) of dimethylphosphate, dimethylthiophosphate and diethylphosphate, which had a detection rate of 50% or higher, were 3.53 (1.91–6.78), 4.09 (1.66–10.8) and 3.28 (1.88–5.98) µg/g-creatinine, respectively. Possible predictors of urinary DAP concentrations were the month of urine sampling, consumption of apple and maternal body mass index. When fenitrothion was used as an index chemical for cumulative risk assessment, 0.36% of participants exceeded the lower 95% confidence limit of the benchmark dose 10 .

Suggested Citation

  • Yukiko Nishihama & Shoji F. Nakayama & Tomohiko Isobe & Chau-Ren Jung & Miyuki Iwai-Shimada & Yayoi Kobayashi & Takehiro Michikawa & Makiko Sekiyama & Yu Taniguchi & Shin Yamazaki & on behalf of the J, 2021. "Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)," IJERPH, MDPI, vol. 18(11), pages 1-13, May.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:11:p:5929-:d:566558
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    References listed on IDEAS

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    1. Neeranuch Suwannarin & Tippawan Prapamontol & Tomohiko Isobe & Yukiko Nishihama & Shoji F. Nakayama, 2020. "Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study," IJERPH, MDPI, vol. 17(21), pages 1-14, October.
    2. Runmin Wei & Jingye Wang & Erik Jia & Tianlu Chen & Yan Ni & Wei Jia, 2018. "GSimp: A Gibbs sampler based left-censored missing value imputation approach for metabolomics studies," PLOS Computational Biology, Public Library of Science, vol. 14(1), pages 1-14, January.
    Full references (including those not matched with items on IDEAS)

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