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Changes of Somatosensory Phenotype in the Course of Disease in Osteoarthritis Patients

Author

Listed:
  • Johanna Höper

    (Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany
    Equally contributed.)

  • Lara Schraml

    (Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany
    Equally contributed.)

  • Janne Gierthmühlen

    (Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany)

  • Stephanie M. Helfert

    (Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany)

  • Stefanie Rehm

    (Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany)

  • Susanne Härtig

    (Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany)

  • Ove Schröder

    (Department of Orthopedics and Trauma Surgery, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany)

  • Michael Lankes

    (Private Practice for Orthopedics and Trauma Surgery am Arndtplatz, 24116 Kiel, Germany)

  • Frieder C. Traulsen

    (Private Practice for Orthopedics and Trauma Surgery am Arndtplatz, 24116 Kiel, Germany)

  • Andreas Seekamp

    (Department of Orthopedics and Trauma Surgery, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany)

  • Ralf Baron

    (Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany)

Abstract

To investigate sensory changes, physical function (pF), quality of life (QoL) and pain intensity of patients with osteoarthritis (OA) in the natural course of disease, and patients undergoing total joint replacement therapy (TJR) 31 (20 females, mean age 64.6 ± 10.4 years), patients with OA were investigated with questionnaires and quantitative sensory testing (QST) in the area of referred pain at the thigh at baseline and follow-up 22–49 weeks later; changes were analyzed separately for patients with ( n = 13) and without TJR ( n = 18). In patients without TJR pain intensity, pF, QoL did not improve, and increased pain sensitivity to cold and a stronger loss of detection were observed. In patients after TJR, however, a reduction in mechanical pain sensitivity and allodynia occurred in accordance with a reduction of pain intensity and improvement of functionality while QoL did not improve. Additionally, an increased sensitivity to heat pain and a more pronounced loss of mechanical detection could be observed in this group. TJR seems to stop peripheral pain input leading to a reduction of pain intensity and central sensitization, but surgery-induced sensory changes such as peripheral sensitization and loss of detection occur. Furthermore, TJR has favorable effects on pain intensity and functionality but not QoL.

Suggested Citation

  • Johanna Höper & Lara Schraml & Janne Gierthmühlen & Stephanie M. Helfert & Stefanie Rehm & Susanne Härtig & Ove Schröder & Michael Lankes & Frieder C. Traulsen & Andreas Seekamp & Ralf Baron, 2020. "Changes of Somatosensory Phenotype in the Course of Disease in Osteoarthritis Patients," IJERPH, MDPI, vol. 17(9), pages 1-11, April.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:9:p:3085-:d:351766
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    References listed on IDEAS

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    1. Bullinger, Monika, 1995. "German translation and psychometric testing of the SF-36 Health Survey: Preliminary results from the IQOLA project," Social Science & Medicine, Elsevier, vol. 41(10), pages 1359-1366, November.
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