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Addition of Probiotics to Anti-Obesity Therapy by Percutaneous Electrical Stimulation of Dermatome T6. A Pilot Study

Author

Listed:
  • Oscar Lorenzo

    (Laboratory of Diabetes and Vascular Pathology, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, Spain
    Spanish Biomedical Research Centre on Diabetes and Associated Metabolic Disorders (CIBERDEM) Network, 28040 Madrid, Spain)

  • Marta Crespo-Yanguas

    (Laboratory of Diabetes and Vascular Pathology, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, Spain)

  • Tianyu Hang

    (Laboratory of Diabetes and Vascular Pathology, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, Spain)

  • Jairo Lumpuy-Castillo

    (Laboratory of Diabetes and Vascular Pathology, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, Spain)

  • Artur M. Hernández

    (Department of Sport Sciences, Universidad Europea de Madrid, 28670 Villaviciosa de Odón-Madrid, Spain)

  • Carolina Llavero

    (Obesity Unit, Clinica Garcilaso, 28010 Madrid, Spain)

  • MLuisa García-Alonso

    (Laboratory of Diabetes and Vascular Pathology, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, Spain)

  • Jaime Ruiz-Tovar

    (Obesity Unit, Clinica Garcilaso, 28010 Madrid, Spain
    Department of Health Sciences, Universidad Rey Juan Carlos, 28933 Mostoles-Madrid, Spain)

Abstract

Obesity is becoming a pandemic and percutaneous electrical stimulation (PENS) of dermatome T6 has been demonstrated to reduce stomach motility and appetite, allowing greater weight loss than isolated hypocaloric diets. However, modulation of intestinal microbiota could improve this effect and control cardiovascular risk factors. Our objective was to test whether addition of probiotics could improve weight loss and cardiovascular risk factors in obese subjects after PENS and a hypocaloric diet. A pilot prospective study was performed in patients ( n = 20) with a body mass index (BMI) > 30 kg/m 2 . Half of them underwent ten weeks of PENS in conjunction with a hypocaloric diet (PENS-Diet), and the other half was treated with a PENS-Diet plus multistrain probiotics ( L. plantarum LP115 , B. brevis B3 , and L. acidophilus LA14 ) administration. Fecal samples were obtained before and after interventions. The weight loss and changes in blood pressure, glycemic and lipid profile, and in gut microbiota were investigated. Weight loss was significantly higher (16.2 vs. 11.1 kg, p = 0.022), whereas glycated hemoglobin and triglycerides were lower (−0.46 vs. −0.05%, p = 0.032, and −47.0 vs. −8.5 mg/dL, p = 0.002, respectively) in patients receiving PENS-Diet + probiotics compared with those with a PENS-Diet. Moreover, an enrichment of anti-obesogenic bacteria, including Bifidobacterium spp, Akkermansia spp, Prevotella spp , and the attenuation of the Firmicutes/Bacteroidetes ratio were noted in fecal samples after probiotics administration. In obese patients, the addition of probiotics to a PENS intervention under a hypocaloric diet could further improve weight loss and glycemic and lipid profile in parallel to the amelioration of gut dysbiosis.

Suggested Citation

  • Oscar Lorenzo & Marta Crespo-Yanguas & Tianyu Hang & Jairo Lumpuy-Castillo & Artur M. Hernández & Carolina Llavero & MLuisa García-Alonso & Jaime Ruiz-Tovar, 2020. "Addition of Probiotics to Anti-Obesity Therapy by Percutaneous Electrical Stimulation of Dermatome T6. A Pilot Study," IJERPH, MDPI, vol. 17(19), pages 1-14, October.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:19:p:7239-:d:423561
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    References listed on IDEAS

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    1. Catherine A. Lozupone & Jesse I. Stombaugh & Jeffrey I. Gordon & Janet K. Jansson & Rob Knight, 2012. "Diversity, stability and resilience of the human gut microbiota," Nature, Nature, vol. 489(7415), pages 220-230, September.
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    Cited by:

    1. Diana Cardona & Pablo Roman, 2022. "New Perspectives in Health: Gut Microbiota," IJERPH, MDPI, vol. 19(10), pages 1-3, May.

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