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Diversity, stability and resilience of the human gut microbiota

Author

Listed:
  • Catherine A. Lozupone

    (University of Colorado)

  • Jesse I. Stombaugh

    (University of Colorado)

  • Jeffrey I. Gordon

    (Center for Genome Sciences and Systems Biology, Washington University in St. Louis)

  • Janet K. Jansson

    (Lawrence Berkeley National Laboratory
    Joint Genome Institute, Lawrence Berkeley National Laboratory)

  • Rob Knight

    (University of Colorado
    Howard Hughes Medical Institute
    Biofrontiers Institute, University of Colorado)

Abstract

Trillions of microbes inhabit the human intestine, forming a complex ecological community that influences normal physiology and susceptibility to disease through its collective metabolic activities and host interactions. Understanding the factors that underlie changes in the composition and function of the gut microbiota will aid in the design of therapies that target it. This goal is formidable. The gut microbiota is immensely diverse, varies between individuals and can fluctuate over time — especially during disease and early development. Viewing the microbiota from an ecological perspective could provide insight into how to promote health by targeting this microbial community in clinical treatments.

Suggested Citation

  • Catherine A. Lozupone & Jesse I. Stombaugh & Jeffrey I. Gordon & Janet K. Jansson & Rob Knight, 2012. "Diversity, stability and resilience of the human gut microbiota," Nature, Nature, vol. 489(7415), pages 220-230, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7415:d:10.1038_nature11550
    DOI: 10.1038/nature11550
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    Cited by:

    1. Liyan Song, 2023. "Toward Understanding Microbial Ecology to Restore a Degraded Ecosystem," IJERPH, MDPI, vol. 20(5), pages 1-9, March.
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    3. Qiwen Cheng & Rosa Krajmalnik-Brown & John K. DiBaise & Juan Maldonado & M. Aaron Guest & Michael Todd & Shelby L. Langer, 2023. "Relationship Functioning and Gut Microbiota Composition among Older Adult Couples," IJERPH, MDPI, vol. 20(8), pages 1-17, April.
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    5. Lena Takayasu & Wataru Suda & Eiichiro Watanabe & Shinji Fukuda & Kageyasu Takanashi & Hiroshi Ohno & Misako Takayasu & Hideki Takayasu & Masahira Hattori, 2017. "A 3-dimensional mathematical model of microbial proliferation that generates the characteristic cumulative relative abundance distributions in gut microbiomes," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-20, August.
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    12. Kiran Konain & Sadia & Turfa Nadeem & Adeed Khan & Warda Iqbal & Arsalan & Amir Javed & Ruby Khan & Kainat Jamil & Kainat Jamil, 2018. "Importance of Probiotics in Gastrointestinal Tract," Journal of Asian Scientific Research, Asian Economic and Social Society, vol. 8(3), pages 128-143, March.
    13. Debanjan Mukherjee & Ângelo Ferreira Chora & Jean-Christophe Lone & Ricardo S. Ramiro & Birte Blankenhaus & Karine Serre & Mário Ramirez & Isabel Gordo & Marc Veldhoen & Patrick Varga-Weisz & Maria M., 2022. "Host lung microbiota promotes malaria-associated acute respiratory distress syndrome," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    14. Sarah L Hagerty & Kent E Hutchison & Christopher A Lowry & Angela D Bryan, 2020. "An empirically derived method for measuring human gut microbiome alpha diversity: Demonstrated utility in predicting health-related outcomes among a human clinical sample," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-21, March.
    15. Khalilullah Mayar & David G. Carmichael & Xuesong Shen, 2022. "Resilience and Systems—A Review," Sustainability, MDPI, vol. 14(14), pages 1-22, July.
    16. Jakob Woerner & Yidi Huang & Stephan Hutter & Carmelo Gurnari & Jesús María Hernández Sánchez & Janet Wang & Yimin Huang & Daniel Schnabel & Michael Aaby & Wanying Xu & Vedant Thorat & Dongxu Jiang & , 2022. "Circulating microbial content in myeloid malignancy patients is associated with disease subtypes and patient outcomes," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    17. Hannah E. Laue & Yike Shen & Tessa R. Bloomquist & Haotian Wu & Kasey J. M. Brennan & Raphael Cassoulet & Erin Wilkie & Virginie Gillet & Anne-Sandrine Desautels & Nadia Abdelouahab & Jean Philippe Be, 2022. "In Utero Exposure to Caffeine and Acetaminophen, the Gut Microbiome, and Neurodevelopmental Outcomes: A Prospective Birth Cohort Study," IJERPH, MDPI, vol. 19(15), pages 1-14, July.
    18. Daniel J Reis & Stephen S Ilardi & Stephanie E W Punt, 2018. "The anxiolytic effect of probiotics: A systematic review and meta-analysis of the clinical and preclinical literature," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-25, June.
    19. Gregory E Miller & Phillip A Engen & Patrick M Gillevet & Maliha Shaikh & Masoumeh Sikaroodi & Christopher B Forsyth & Ece Mutlu & Ali Keshavarzian, 2016. "Lower Neighborhood Socioeconomic Status Associated with Reduced Diversity of the Colonic Microbiota in Healthy Adults," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-17, February.
    20. Bazeia, D. & Bongestab, M. & de Oliveira, B.F. & Szolnoki, A., 2021. "Effects of a pestilent species on the stability of cyclically dominant species," Chaos, Solitons & Fractals, Elsevier, vol. 151(C).
    21. Jonathan W. Lo & Domenico Cozzetto & James L. Alexander & Nathan P. Danckert & Matthew Madgwick & Naomi Knox & Jillian Yong Xin Sieh & Marton Olbei & Zhigang Liu & Hajir Ibraheim & Jesus Miguens Blanc, 2023. "Immune checkpoint inhibitor-induced colitis is mediated by polyfunctional lymphocytes and is dependent on an IL23/IFNγ axis," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    22. Xiaolong Xue & Liang Wang & Rebecca J. Yang, 2018. "Exploring the science of resilience: critical review and bibliometric analysis," Natural Hazards: Journal of the International Society for the Prevention and Mitigation of Natural Hazards, Springer;International Society for the Prevention and Mitigation of Natural Hazards, vol. 90(1), pages 477-510, January.
    23. Oscar Lorenzo & Marta Crespo-Yanguas & Tianyu Hang & Jairo Lumpuy-Castillo & Artur M. Hernández & Carolina Llavero & MLuisa García-Alonso & Jaime Ruiz-Tovar, 2020. "Addition of Probiotics to Anti-Obesity Therapy by Percutaneous Electrical Stimulation of Dermatome T6. A Pilot Study," IJERPH, MDPI, vol. 17(19), pages 1-14, October.

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