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Modeling effective transmission pathways and control of the world’s most successful parasite

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  • Turner, Matthew
  • Lenhart, Suzanne
  • Rosenthal, Benjamin
  • Zhao, Xiaopeng

Abstract

Toxoplasma gondii(T. gondii) is a single-celled, intracellular protozoan responsible for the disease toxoplasmosis. The parasite is prevalent worldwide, and it infects all warm-blooded vertebrates. Consumption of meats in which this parasite has encysted confers risk of infection to people and other animals, as does ingestion of water or foods contaminated with environmentally resistant oocysts excreted by cats. Vertical transmission (from mother to offspring) is also possible, leading to disease risk and contributing additional means of ensuring perpetuation of transmission. In this work, we adopt a differential equation model to investigate the effective transmission pathways of T. gondii, as well as potential control mechanisms. Detailed analyses are carried out to examine the significance of transmission routes, virulence, vertical transmission, parasite-induced changes in host behavior, and controls based on vaccination and harvesting. Modeling and analysis efforts may shed insights into understanding the complex life cycle of T. gondii.

Suggested Citation

  • Turner, Matthew & Lenhart, Suzanne & Rosenthal, Benjamin & Zhao, Xiaopeng, 2013. "Modeling effective transmission pathways and control of the world’s most successful parasite," Theoretical Population Biology, Elsevier, vol. 86(C), pages 50-61.
    • Handle: RePEc:eee:thpobi:v:86:y:2013:i:c:p:50-61
    DOI: 10.1016/j.tpb.2013.04.001
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    References listed on IDEAS

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    1. Arenas, Abraham J. & González-Parra, Gilberto & Villanueva Micó, Rafael-J., 2010. "Modeling toxoplasmosis spread in cat populations under vaccination," Theoretical Population Biology, Elsevier, vol. 77(4), pages 227-237.
    2. N. J. Welton & A. E. Ades, 2005. "A model of toxoplasmosis incidence in the UK: evidence synthesis and consistency of evidence," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 54(2), pages 385-404, April.
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    Cited by:

    1. Sharmin Sultana & Gilberto González-Parra & Abraham J. Arenas, 2023. "Mathematical Modeling of Toxoplasmosis in Cats with Two Time Delays under Environmental Effects," Mathematics, MDPI, vol. 11(16), pages 1-20, August.
    2. Sykes, David & Rychtář, Jan, 2015. "A game-theoretic approach to valuating toxoplasmosis vaccination strategies," Theoretical Population Biology, Elsevier, vol. 105(C), pages 33-38.

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