On a resampling approach for tests on the number of clusters with mixture model-based clustering of tissue samples
We consider the problem of assessing the number of clusters in a limited number of tissue samples containing gene expressions for possibly several thousands of genes. It is proposed to use a normal mixture model-based approach to the clustering of the tissue samples. One advantage of this approach is that the question on the number of clusters in the data can be formulated in terms of a test on the smallest number of components in the mixture model compatible with the data. This test can be carried out on the basis of the likelihood ratio test statistic, using resampling to assess its null distribution. The effectiveness of this approach is demonstrated on simulated data and on some microarray datasets, as considered previously in the bioinformatics literature.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.
Volume (Year): 90 (2004)
Issue (Month): 1 (July)
|Contact details of provider:|| Web page: http://www.elsevier.com/wps/find/journaldescription.cws_home/622892/description#description|
|Order Information:|| Postal: http://www.elsevier.com/wps/find/supportfaq.cws_home/regional|
References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Coleman, Dan & Dong, Xioapeng & Hardin, Johanna & Rocke, David M. & Woodruff, David L., 1999. "Some computational issues in cluster analysis with no a priori metric," Computational Statistics & Data Analysis, Elsevier, vol. 31(1), pages 1-11, July.
- Robert Tibshirani & Guenther Walther & Trevor Hastie, 2001. "Estimating the number of clusters in a data set via the gap statistic," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 63(2), pages 411-423.
- J. Hartigan, 1985. "Statistical theory in clustering," Journal of Classification, Springer;The Classification Society, vol. 2(1), pages 63-76, December.
- McLachlan, G. J. & Peel, D. & Bean, R. W., 2003. "Modelling high-dimensional data by mixtures of factor analyzers," Computational Statistics & Data Analysis, Elsevier, vol. 41(3-4), pages 379-388, January.
- Allison, David B. & Gadbury, Gary L. & Heo, Moonseong & Fernandez, Jose R. & Lee, Cheol-Koo & Prolla, Tomas A. & Weindruch, Richard, 2002. "A mixture model approach for the analysis of microarray gene expression data," Computational Statistics & Data Analysis, Elsevier, vol. 39(1), pages 1-20, March.
- Huber Wolfgang & von Heydebreck Anja & Sueltmann Holger & Poustka Annemarie & Vingron Martin, 2003. "Parameter estimation for the calibration and variance stabilization of microarray data," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 2(1), pages 1-24, April.
When requesting a correction, please mention this item's handle: RePEc:eee:jmvana:v:90:y:2004:i:1:p:90-105. See general information about how to correct material in RePEc.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Shamier, Wendy)
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If references are entirely missing, you can add them using this form.
If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.
Please note that corrections may take a couple of weeks to filter through the various RePEc services.