IDEAS home Printed from https://ideas.repec.org/a/eee/csdana/v53y2009i5p1650-1660.html
   My bibliography  Save this article

Distribution modeling and simulation of gene expression data

Author

Listed:
  • Parrish, Rudolph S.
  • Spencer III, Horace J.
  • Xu, Ping

Abstract

Data derived from gene expression microarrays often are used for purposes of classification and discovery. Many methods have been proposed for accomplishing these and related aims, however the statistical properties of such methods generally are not well established. To this end, it is desirable to develop realistic mathematical and statistical models that can be used in a simulation context so that the impacts of data analysis methods and testing approaches can be established. A method is developed in which variation among arrays can be characterized simultaneously for a large number of genes resulting in a multivariate model of gene expression. The method is based on selecting mathematical transformations of the underlying expression measures such that the transformed variables follow approximately a Gaussian distribution, and then estimating associated parameters, including correlations. The result is a multivariate normal distribution that serves to model transformed gene expression values within a subject population, while accounting for covariances among genes and/or probes. This model then is used to simulate microarray expression and probe intensity data by employing a modified Cholesky matrix factorization technique which addresses the singularity problem for the "small n, big p" situation. An example is given using prostate cancer data and, as an illustration, it is shown how data normalization can be investigated using this approach.

Suggested Citation

  • Parrish, Rudolph S. & Spencer III, Horace J. & Xu, Ping, 2009. "Distribution modeling and simulation of gene expression data," Computational Statistics & Data Analysis, Elsevier, vol. 53(5), pages 1650-1660, March.
    • Handle: RePEc:eee:csdana:v:53:y:2009:i:5:p:1650-1660
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0167-9473(08)00196-5
    Download Restriction: Full text for ScienceDirect subscribers only.
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Xu, Ping & Brock, Guy N. & Parrish, Rudolph S., 2009. "Modified linear discriminant analysis approaches for classification of high-dimensional microarray data," Computational Statistics & Data Analysis, Elsevier, vol. 53(5), pages 1674-1687, March.
    2. Allison, David B. & Gadbury, Gary L. & Heo, Moonseong & Fernandez, Jose R. & Lee, Cheol-Koo & Prolla, Tomas A. & Weindruch, Richard, 2002. "A mixture model approach for the analysis of microarray gene expression data," Computational Statistics & Data Analysis, Elsevier, vol. 39(1), pages 1-20, March.
    3. Danh V. Nguyen & A. Bulak Arpat & Naisyin Wang & Raymond J. Carroll, 2002. "DNA Microarray Experiments: Biological and Technological Aspects," Biometrics, The International Biometric Society, vol. 58(4), pages 701-717, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Tsai, Arthur C. & Liou, Michelle & Simak, Maria & Cheng, Philip E., 2017. "On hyperbolic transformations to normality," Computational Statistics & Data Analysis, Elsevier, vol. 115(C), pages 250-266.
    2. Xu, Ping & Brock, Guy N. & Parrish, Rudolph S., 2009. "Modified linear discriminant analysis approaches for classification of high-dimensional microarray data," Computational Statistics & Data Analysis, Elsevier, vol. 53(5), pages 1674-1687, March.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Robert R. Delongchamp & John F. Bowyer & James J. Chen & Ralph L. Kodell, 2004. "Multiple-Testing Strategy for Analyzing cDNA Array Data on Gene Expression," Biometrics, The International Biometric Society, vol. 60(3), pages 774-782, September.
    2. Frénay, Benoît & Doquire, Gauthier & Verleysen, Michel, 2014. "Estimating mutual information for feature selection in the presence of label noise," Computational Statistics & Data Analysis, Elsevier, vol. 71(C), pages 832-848.
    3. Li-Xuan Qin & Steven G. Self, 2006. "The Clustering of Regression Models Method with Applications in Gene Expression Data," Biometrics, The International Biometric Society, vol. 62(2), pages 526-533, June.
    4. Ghosh Debashis, 2012. "Incorporating the Empirical Null Hypothesis into the Benjamini-Hochberg Procedure," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 11(4), pages 1-21, July.
    5. Long Qu & Tobias Guennel & Scott L. Marshall, 2013. "Linear Score Tests for Variance Components in Linear Mixed Models and Applications to Genetic Association Studies," Biometrics, The International Biometric Society, vol. 69(4), pages 883-892, December.
    6. Ivana Krtolica & Dragan Savić & Bojana Bajić & Snežana Radulović, 2022. "Machine Learning for Water Quality Assessment Based on Macrophyte Presence," Sustainability, MDPI, vol. 15(1), pages 1-13, December.
    7. He, Yi & Pan, Wei & Lin, Jizhen, 2006. "Cluster analysis using multivariate normal mixture models to detect differential gene expression with microarray data," Computational Statistics & Data Analysis, Elsevier, vol. 51(2), pages 641-658, November.
    8. Lin Zhang & Inyoung Kim, 2021. "Finite mixtures of semiparametric Bayesian survival kernel machine regressions: Application to breast cancer gene pathway subgroup analysis," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 70(2), pages 251-269, March.
    9. Raymond J. Carroll, 2003. "Variances Are Not Always Nuisance Parameters," Biometrics, The International Biometric Society, vol. 59(2), pages 211-220, June.
    10. Cheng, Cheng, 2009. "Internal validation inferences of significant genomic features in genome-wide screening," Computational Statistics & Data Analysis, Elsevier, vol. 53(3), pages 788-800, January.
    11. A. Poterie & J.-F. Dupuy & V. Monbet & L. Rouvière, 2019. "Classification tree algorithm for grouped variables," Computational Statistics, Springer, vol. 34(4), pages 1613-1648, December.
    12. Brendan P. W. Ames & Mingyi Hong, 2016. "Alternating direction method of multipliers for penalized zero-variance discriminant analysis," Computational Optimization and Applications, Springer, vol. 64(3), pages 725-754, July.
    13. Xiang, Qinfang & Edwards, Jode & Gadbury, Gary L., 2006. "Interval estimation in a finite mixture model: Modeling P-values in multiple testing applications," Computational Statistics & Data Analysis, Elsevier, vol. 51(2), pages 570-586, November.
    14. Gary L Gadbury & David B Allison, 2012. "Inappropriate Fiddling with Statistical Analyses to Obtain a Desirable P-value: Tests to Detect its Presence in Published Literature," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-9, October.
    15. Charnigo, Richard & Fan, Qian & Bittel, Douglas & Dai, Hongying, 2013. "Testing unilateral versus bilateral normal contamination," Statistics & Probability Letters, Elsevier, vol. 83(1), pages 163-167.
    16. Shigeyuki Matsui & Shu Zeng & Takeharu Yamanaka & John Shaughnessy, 2008. "Sample Size Calculations Based on Ranking and Selection in Microarray Experiments," Biometrics, The International Biometric Society, vol. 64(1), pages 217-226, March.
    17. Kubokawa, Tatsuya & Hyodo, Masashi & Srivastava, Muni S., 2013. "Asymptotic expansion and estimation of EPMC for linear classification rules in high dimension," Journal of Multivariate Analysis, Elsevier, vol. 115(C), pages 496-515.
    18. Irina Gaynanova & James G. Booth & Martin T. Wells, 2016. "Simultaneous Sparse Estimation of Canonical Vectors in the ≫ Setting," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(514), pages 696-706, April.
    19. Yongqiang Tang & Subhashis Ghosal & Anindya Roy, 2007. "Nonparametric Bayesian Estimation of Positive False Discovery Rates," Biometrics, The International Biometric Society, vol. 63(4), pages 1126-1134, December.
    20. Sung, Bongjung & Lee, Jaeyong, 2023. "Covariance structure estimation with Laplace approximation," Journal of Multivariate Analysis, Elsevier, vol. 198(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:csdana:v:53:y:2009:i:5:p:1650-1660. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/locate/csda .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.