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Funding breakthrough therapies: A systematic review and recommendation


  • Hanna, E.
  • Toumi, M.
  • Dussart, C.
  • Borissov, B.
  • Dabbous, O.
  • Badora, K.
  • Auquier, P.


Advanced therapy medicinal products (ATMPs) are innovative therapies likely associated with high prices. Payers need guidance to create a balance between ensuring patient access to breakthrough therapies and maintaining the financial sustainability of the healthcare system.

Suggested Citation

  • Hanna, E. & Toumi, M. & Dussart, C. & Borissov, B. & Dabbous, O. & Badora, K. & Auquier, P., 2018. "Funding breakthrough therapies: A systematic review and recommendation," Health Policy, Elsevier, vol. 122(3), pages 217-229.
  • Handle: RePEc:eee:hepoli:v:122:y:2018:i:3:p:217-229
    DOI: 10.1016/j.healthpol.2017.11.012

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    References listed on IDEAS

    1. Garau, M. & Mestre-Ferrandiz, J., 2009. "Access Mechanisms for Orphan Drugs: A Comparative Study of Selected European Countries," Briefings 000227, Office of Health Economics.
    2. Marsden, G. & Towse, A. & Pearson, S.D & Dreitlein, B. & Henshall, C., 2017. "Gene Therapy: Understanding the Science, Assessing the Evidence, and Paying for Value," Research Papers 001811, Office of Health Economics.
    3. Arieh Gavious & Dan Greenberg & Ariel Hammerman & Ella Segev, 2014. "Impact of a financial risk-sharing scheme on budget-impact estimations: a game-theoretic approach," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 15(5), pages 553-561, June.
    4. Ulf Persson & Johanna Svensson & Billie Pettersson, 2012. "A New Reimbursement System for Innovative Pharmaceuticals Combining Value-Based and Free Market Pricing," Applied Health Economics and Health Policy, Springer, vol. 10(4), pages 217-225, July.
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