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Modelling effects of a chemotherapeutic dose response on a stochastic tumour-immune model

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  • Yang, Jin
  • Tan, Yuanshun
  • Cheke, Robert A.

Abstract

A stochastic tumour-immune dynamical system with pulsed chemotherapeutic dose response is proposed to study how environmental noise affects the evolution of tumours. Firstly, the explicit expression of a tumour-free solution is obtained and then we show that the proposed system exists with a globally asymptotically stable positive solution under certain conditions. Secondly, threshold criteria ensuring the eradication and persistence of tumours are provided. Numerical investigations were carried out to address the effects of key factors on the tumours. The results reveal that environmental noise can dominate all of the tumour dynamics, but comprehensive therapy can not only accelerate the eradication of tumours, but also avoid the disadvantages of a single therapy.

Suggested Citation

  • Yang, Jin & Tan, Yuanshun & Cheke, Robert A., 2019. "Modelling effects of a chemotherapeutic dose response on a stochastic tumour-immune model," Chaos, Solitons & Fractals, Elsevier, vol. 123(C), pages 1-13.
    • Handle: RePEc:eee:chsofr:v:123:y:2019:i:c:p:1-13
    DOI: 10.1016/j.chaos.2019.03.029
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    References listed on IDEAS

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    1. Yang, Jin & Tang, Sanyi & Cheke, Robert A., 2015. "Modelling pulsed immunotherapy of tumour–immune interaction," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 109(C), pages 92-112.
    2. Lu, Qiuying, 2009. "Stability of SIRS system with random perturbations," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 388(18), pages 3677-3686.
    3. Yang, Xiaofeng & Jin, Zhen & Xue, Yakui, 2007. "Weak average persistence and extinction of a predator–prey system in a polluted environment with impulsive toxicant input," Chaos, Solitons & Fractals, Elsevier, vol. 31(3), pages 726-735.
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    Cited by:

    1. Yang, Huan & Tan, Yuanshun & Yang, Jin & Liu, Zijian, 2021. "Extinction and persistence of a tumor-immune model with white noise and pulsed comprehensive therapy," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 182(C), pages 456-470.
    2. Zhao, Zhong & Pang, Liuyong & Li, Qiuying, 2021. "Analysis of a hybrid impulsive tumor-immune model with immunotherapy and chemotherapy," Chaos, Solitons & Fractals, Elsevier, vol. 144(C).

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