IDEAS home Printed from https://ideas.repec.org/a/bla/istatr/v82y2014i1p106-122.html
   My bibliography  Save this article

Non-parametric Analysis of Gap Times for Multiple Event Data: An Overview

Author

Listed:
  • Hong Zhu

Abstract

type="main" xml:id="insr12031-abs-0001"> Multiple event data are frequently encountered in medical follow-up, engineering and other applications when the multiple events are considered as the major outcomes. They may be repetitions of the same event (recurrent events) or may be events of different nature. Times between successive events (gap times) are often of direct interest in these applications. The stochastic-ordering structure and within-subject dependence of multiple events generate statistical challenges for analysing such data, including induced dependent censoring and non-identifiability of marginal distributions. This paper provides an overview of a class of existing non-parametric estimation methods for gap time distributions for various types of multiple event data, where sampling bias from induced dependent censoring is effectively adjusted. We discuss the statistical issues in gap time analysis, describe the estimation procedures and illustrate the methods with a comparative simulation study and a real application to an AIDS clinical trial. A comprehensive understanding of challenges and available methods for non-parametric analysis can be useful because there is no existing standard approach to identifying an appropriate gap time method that can be used to address research question of interest. The methods discussed in this review would allow practitioners to effectively handle a variety of real-world multiple event data.

Suggested Citation

  • Hong Zhu, 2014. "Non-parametric Analysis of Gap Times for Multiple Event Data: An Overview," International Statistical Review, International Statistical Institute, vol. 82(1), pages 106-122, April.
    • Handle: RePEc:bla:istatr:v:82:y:2014:i:1:p:106-122
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1111/insr.12031
    Download Restriction: Access to full text is restricted to subscribers.
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Chiung-Yu Huang & Mei-Cheng Wang, 2005. "Nonparametric Estimation of the Bivariate Recurrence Time Distribution," Biometrics, The International Biometric Society, vol. 61(2), pages 392-402, June.
    2. Pena E.A. & Strawderman R.L. & Hollander M., 2001. "Nonparametric Estimation With Recurrent Event Data," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 1299-1315, December.
    3. Douglas E. Schaubel, 2004. "Regression methods for gap time hazard functions of sequentially ordered multivariate failure time data," Biometrika, Biometrika Trust, vol. 91(2), pages 291-303, June.
    4. D. Y. Lin & L. J. Wei & I. Yang & Z. Ying, 2000. "Semiparametric regression for the mean and rate functions of recurrent events," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 62(4), pages 711-730.
    5. D. Y. Lin & Zhiliang Ying, 2001. "Nonparametric Tests for the Gap Time Distributions of Serial Events Based on Censored Data," Biometrics, The International Biometric Society, vol. 57(2), pages 369-375, June.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Dennis D. Boos & Jason A. Osborne, 2015. "Assessing Variability of Complex Descriptive Statistics in Monte Carlo Studies Using Resampling Methods," International Statistical Review, International Statistical Institute, vol. 83(2), pages 228-238, August.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Shen, Pao-sheng, 2015. "The inverse probability weighted estimators for distribution functions of the bivariate recurrent events," Statistics & Probability Letters, Elsevier, vol. 106(C), pages 91-99.
    2. Laura M. Yee & Kwun Chuen Gary Chan, 2017. "Nonparametric inference for the joint distribution of recurrent marked variables and recurrent survival time," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(2), pages 207-222, April.
    3. Jean‐Yves Dauxois & Sophie Sencey, 2009. "Non‐parametric Tests for Recurrent Events under Competing Risks," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 36(4), pages 649-670, December.
    4. Sankaran, P.G. & Anisha, P., 2012. "Additive hazards models for gap time data with multiple causes," Statistics & Probability Letters, Elsevier, vol. 82(7), pages 1454-1462.
    5. Xiaoyan Sun & Limin Peng & Yijian Huang & HuiChuan J. Lai, 2016. "Generalizing Quantile Regression for Counting Processes With Applications to Recurrent Events," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(513), pages 145-156, March.
    6. Russell T. Shinohara & Yifei Sun & Mei-Cheng Wang, 2018. "Alternating event processes during lifetimes: population dynamics and statistical inference," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 24(1), pages 110-125, January.
    7. V. N. Sreeja & P. G. Sankaran, 2007. "Proportional mean residual life model for gap time distributions of recurrent events," Metron - International Journal of Statistics, Dipartimento di Statistica, Probabilità e Statistiche Applicate - University of Rome, vol. 0(3), pages 319-336.
    8. Lili Wang & Kevin He & Douglas E. Schaubel, 2020. "Penalized survival models for the analysis of alternating recurrent event data," Biometrics, The International Biometric Society, vol. 76(2), pages 448-459, June.
    9. Zhao, Xiaobing & Zhou, Xian, 2012. "Modeling gap times between recurrent events by marginal rate function," Computational Statistics & Data Analysis, Elsevier, vol. 56(2), pages 370-383.
    10. Zhao, Xiaobing & Zhou, Xian, 2014. "Sufficient dimension reduction on marginal regression for gaps of recurrent events," Journal of Multivariate Analysis, Elsevier, vol. 127(C), pages 56-71.
    11. Jie Fan & Somnath Datta, 2013. "On Mann–Whitney tests for comparing sojourn time distributions when the transition times are right censored," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 65(1), pages 149-166, February.
    12. Kang, Fangyuan & Sun, Liuquan & Zhao, Xingqiu, 2015. "A class of transformed hazards models for recurrent gap times," Computational Statistics & Data Analysis, Elsevier, vol. 83(C), pages 151-167.
    13. Jieli Ding & Liuquan Sun, 2017. "Additive mixed effect model for recurrent gap time data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(2), pages 223-253, April.
    14. P. G. Sankaran & P. Anisha, 2011. "Shared frailty model for recurrent event data with multiple causes," Journal of Applied Statistics, Taylor & Francis Journals, vol. 38(12), pages 2859-2868, February.
    15. Chiung-Yu Huang & Mei-Cheng Wang, 2005. "Nonparametric Estimation of the Bivariate Recurrence Time Distribution," Biometrics, The International Biometric Society, vol. 61(2), pages 392-402, June.
    16. Poulami Maitra & Leila D. A. F. Amorim & Jianwen Cai, 2020. "Multiplicative rates model for recurrent events in case-cohort studies," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 26(1), pages 134-157, January.
    17. Na Cai & Wenbin Lu & Hao Helen Zhang, 2012. "Time-Varying Latent Effect Model for Longitudinal Data with Informative Observation Times," Biometrics, The International Biometric Society, vol. 68(4), pages 1093-1102, December.
    18. Julie K. Furberg & Per K. Andersen & Sofie Korn & Morten Overgaard & Henrik Ravn, 2023. "Bivariate pseudo-observations for recurrent event analysis with terminal events," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 29(2), pages 256-287, April.
    19. Xiaowei Sun & Jieli Ding & Liuquan Sun, 2020. "A semiparametric additive rates model for the weighted composite endpoint of recurrent and terminal events," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 26(3), pages 471-492, July.
    20. Jin-Jian Hsieh & A. Adam Ding & Weijing Wang, 2011. "Regression Analysis for Recurrent Events Data under Dependent Censoring," Biometrics, The International Biometric Society, vol. 67(3), pages 719-729, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bla:istatr:v:82:y:2014:i:1:p:106-122. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: https://edirc.repec.org/data/isiiinl.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.