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Critical need for family-based, quasi-experimental designs in integrating genetic and social science research

Author

Listed:
  • D'Onofrio, B.M.
  • Lahey, B.B.
  • Turkheimer, E.
  • Lichtenstein, P.

Abstract

Researchers have identified environmental risks that predict subsequent psychological and medical problems. Based on these correlational findings, researchers have developed and tested complex developmental models and have examined biological moderating factors (e.g., gene- environment interactions). In this context, we stress the critical need for researchers to use familybased, quasi-experimental designs when trying to integrate genetic and social science research involving environmental variables because these designs rigorously examine causal inferences by testing competing hypotheses. We argue that sibling comparison, offspring of twins or siblings, in vitro fertilization designs, and other genetically informed approaches play a unique role in bridging gaps between basic biological and social science research. We use studies on maternal smoking during pregnancy to exemplify these principles.

Suggested Citation

  • D'Onofrio, B.M. & Lahey, B.B. & Turkheimer, E. & Lichtenstein, P., 2013. "Critical need for family-based, quasi-experimental designs in integrating genetic and social science research," American Journal of Public Health, American Public Health Association, vol. 103(SUPPL.1), pages 46-55.
    • Handle: RePEc:aph:ajpbhl:10.2105/ajph.2013.301252_0
    DOI: 10.2105/AJPH.2013.301252
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    Cited by:

    1. Ragnhild E Brandlistuen & Eivind Ystrom & Sonia Hernandez-Diaz & Svetlana Skurtveit & Randi Selmer & Marte Handal & Hedvig Nordeng, 2017. "Association of prenatal exposure to benzodiazepines and child internalizing problems: A sibling-controlled cohort study," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-16, July.
    2. Elizabeth Wall-Wieler & Leslie L. Roos & Dan Chateau & Noralou P. Roos, 2018. "Social Context of Welfare in Manitoba, Canada," Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, Springer, vol. 135(2), pages 661-682, January.
    3. Chen, Juan & Chen, Xi & Leung, Samuel S.M. & Tsang, Hector W.H., 2021. "Potential impacts, alleviating factors, and interventions for children of a parent with schizophrenia: A scoping review," Children and Youth Services Review, Elsevier, vol. 120(C).
    4. Felix C. Tropf & Jornt J. Mandemakers, 2017. "Is the Association Between Education and Fertility Postponement Causal? The Role of Family Background Factors," Demography, Springer;Population Association of America (PAA), vol. 54(1), pages 71-91, February.
    5. Silvia H. Barcellos & Leandro Carvalho & Patrick Turley, 2021. "The Effect of Education on the Relationship between Genetics, Early-Life Disadvantages, and Later-Life SES," NBER Working Papers 28750, National Bureau of Economic Research, Inc.
    6. Jackson, Dylan B., 2016. "The link between poor quality nutrition and childhood antisocial behavior: A genetically informative analysis," Journal of Criminal Justice, Elsevier, vol. 44(C), pages 13-20.
    7. Kateřina Nezvalová-Henriksen & Mollie Wood & Olav Spigset & Hedvig Nordeng, 2016. "Association of Prenatal Ibuprofen Exposure with Birth Weight and Gestational Age: A Population-Based Sibling Study," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-15, December.
    8. Tropf, Felix C & Mandemakers, Jornt J, 2017. "Is the Association Between Education and Fertility Postponement Causal? The Role of Family Background Factors," OSF Preprints dqrrx, Center for Open Science.

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