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Indian Spices and Unhealthy Diets interfere with Drug Therapy in Diabetes and Neurodegenerative Diseases

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  • Ian James Martins

    (Centre of Excellence in Alzheimer’s disease Research and Care, Edith Cowan University, Australia)

Abstract

Nutritional therapy has become important to drug metabolism and treatment with the calorie sensitive gene Sirtuin 1 (Sirt 1) shown to be critical to the prevention of non alcoholic fatty liver disease (NAFLD) with the activation of hepatic drug metabolism. Indian spices have been used extensively in healthy diets in the developing and developed countries for the prevention of NAFLD, diabetes and Alzheimer’s disease. Experimental evidence with relevance to ingestion of Indian spices (mg/day) is limited in various countries. Curcumin intake (mg/day) an amyloid beta aggregation inhibitor for the treatment of Alzheimer’s disease should be carefully controlled to prevent mitophagy and NAFLD. Indian spices that contain Sirt 1 activators such as cinnamon should be consumed to maintain hepatic drug and spice metabolism with the prevention of insulin resistance. Excessive intake of various Indian spices should be avoided to maintain the therapeutic properties of curcumin and cinnamon and to prevent spice-drug or drug-drug interactions. Data on safety and toxicity of Indian spices may indicate that toxic curcumin effects may be related to over ingestion of various Indian spices relevant to drug induced mitochondrial toxicity in NAFLD, diabetes and neurodegenerative diseases.

Suggested Citation

  • Ian James Martins, 2018. "Indian Spices and Unhealthy Diets interfere with Drug Therapy in Diabetes and Neurodegenerative Diseases," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 3(4), pages 73-76, January.
    • Handle: RePEc:adp:jnapdd:v:3:y:2018:i:4:p:73-76
    DOI: 10.19080/NAPDD.2018.03.555616
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    References listed on IDEAS

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    1. Ian James Martins, 2017. "Avasimibe and Sirt 1 Activators Reverse NAFLD and Obesity," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 1(3), pages 38-39, May.
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