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Factors that Determine Fatality of Rhesus Incompatibility

Author

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  • Seriki SA

    (Department of Human Physiology, Edo University, Nigeria)

Abstract

Erythroblastosisfetalis, otherwise described as Haemolytic Disease of the New-born (HDN)occurs when red blood cells (RBC) of fetus break quickly as a result of passage of immunoglobulin-G (IgG) molecules (an antibody produced by the mother) through the placenta into the fetal circulation causing serious reaction that tends to destroy the red cell of the fetus. The current study reviews the pathophysiology of the disease; specifically, it focuses on the factors that determine maternal response to sensitization and also the factors that determine the fatality of response in an exposure. Indeed, it examinesbetween volume of exposure, maternal immune sensitivity and recurrence of exposure, which determines response and fatality. The study observed that although maternal immune sensitivity determines how fast her body responds to sensitization (and not necessarily the volume), the fatality of response is dependent on volume and recurrence of exposure.

Suggested Citation

  • Seriki SA, 2020. "Factors that Determine Fatality of Rhesus Incompatibility," Global Journal of Reproductive Medicine, Juniper Publishers Inc., vol. 7(4), pages 83-852:7, April.
  • Handle: RePEc:adp:jgjorm:v:7:y:2020:i:4:p:83-85
    DOI: 10.19080/GJORM.2020.07.555720
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    Cited by:

    1. Theilen, Bernd & Tomori, Françeska, 2023. "Regulatory commitment versus non-commitment: Electric vehicle adoption under subsidies and emission standards," Resource and Energy Economics, Elsevier, vol. 74(C).

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