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VDR Gene Haplotypes Associate with Type 1 Diabetes and Suggest Interaction with HLA, IL2RA and CTLA4 loci in Colombian Families

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Listed:
  • Natalia Gomez Lopera

    (Grupo Mapeo Genético, Departamento de Pediatría, Facultad de Medicina. Universidad de Antioquia, Colombia)

  • Alejandra Rodriguez

    (Grupo Mapeo Genético, Departamento de Pediatría, Facultad de Medicina. Universidad de Antioquia, Colombia)

  • Martin Toro

    (Seccion de Endocrinología, Departamento de Pediatria, Universidad de Antioquia, Colombia)

  • Maria Victoria Lopera

    (Seccion de Endocrinología, Departamento de Pediatria, Universidad de Antioquia, Colombia)

  • Alejandra Velez

    (Pontificia Universidad Bolivariana, Facultad de Medicina, Colombia)

  • Juan Manuel Alfaro

    (Grupo Mapeo Genético, Departamento de Pediatría, Facultad de Medicina. Universidad de Antioquia, Colombia
    Seccion de Endocrinología, Departamento de Pediatria, Universidad de Antioquia, Colombia)

  • Nicolas Pineda Trujillo

    (Pontificia Universidad Bolivariana, Facultad de Medicina, Colombia)

Abstract

Vitamin D and its receptor are possibly related to T-cell-mediated autoimmune diseases and influences susceptibility to Type 1 diabetes (T1D). The aim of this study was to assess the contribution of vitamin D receptor (VDR) polymorphisms to the susceptibility to T1D in a Colombian sample. Associations of VDR gene variants with T1D were investigated in a sample of 200 familial trios from Colombia. VDR polymorphisms FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236), were determined using PCR-RFLP methodology.

Suggested Citation

  • Natalia Gomez Lopera & Alejandra Rodriguez & Martin Toro & Maria Victoria Lopera & Alejandra Velez & Juan Manuel Alfaro & Nicolas Pineda Trujillo, 2018. "VDR Gene Haplotypes Associate with Type 1 Diabetes and Suggest Interaction with HLA, IL2RA and CTLA4 loci in Colombian Families," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 6(3), pages 42-48, March.
    • Handle: RePEc:adp:jcrdoj:v:6:y:2018:i:3:p:42-48
    DOI: 10.19080/CRDOJ.2018.06.555688
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    References listed on IDEAS

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    1. Guofeng Wang & Qingqing Zhang & Ning Xu & Kuanfeng Xu & Jian Wang & Wei He & Tao Yang, 2014. "Associations between Two Polymorphisms (FokI and BsmI) of Vitamin D Receptor Gene and Type 1 Diabetes Mellitus in Asian Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-7, March.
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    1. Natalia Gomez Lopera & Alejandra Rodriguez & Martin Toro & Maria Victoria Lopera & Alejandra Velez & Juan Manuel Alfaro & Nicolas Pineda Trujillo, 2018. "VDR Gene Haplotypes Associate with Type 1 Diabetes and Suggest Interaction with HLA, IL2RA and CTLA4 loci in Colombian Families," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 6(3), pages 1-7, March.

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    Keywords

    juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal;
    All these keywords.

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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